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general transcription factor IIE, polypeptide 1, alpha 56kDa
Identifiers
Symbol GTF2E1
Alt. symbolsTF2E1
NCBI gene 2960
HGNC 4650
OMIM 189962
RefSeq NM_005513
UniProt P29083
Other data
Locus Chr. 3 q21-q24
Search for
Structures Swiss-model
Domains InterPro
general transcription factor IIE, polypeptide 2, beta 34kDa
Identifiers
Symbol GTF2E2
Alt. symbolsTF2E2
NCBI gene 2961
HGNC 4651
OMIM 189964
RefSeq NM_002095
UniProt P29084
Other data
Locus Chr. 8 p12
Search for
Structures Swiss-model
Domains InterPro

Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. [1] It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein. [2]

TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. [2] Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes. [3] [4] [5] [6] TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA. [7]

See also

References

  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp.  636–637. ISBN  0-13-144946-X.
  2. ^ a b "UniProtKB - P29083 (T2EA_HUMAN)". UniProt. Retrieved 2016-10-19.
  3. ^ Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M (1992). "Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences". Nucleic Acids Res. 20 (21): 5838. doi: 10.1093/nar/20.21.5838. PMC  334425. PMID  1454543.
  4. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi: 10.1093/hmg/3.1.61. PMID  8162052.
  5. ^ Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG (1991). "Conserved sequence motifs in the small subunit of human general transcription factor TFIIE". Nature. 354 (6352): 401–4. Bibcode: 1991Natur.354..401S. doi: 10.1038/354401a0. PMID  1956404. S2CID  4288495.
  6. ^ Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG (December 1991). "Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE". Nature. 354 (6352): 398–401. doi: 10.1038/354398a0. PMID  1956403. S2CID  4325438.
  7. ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi: 10.1146/annurev.genet.34.1.77. PMID  11092823.

External links


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