From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Forkead box I3 (FOXI3) is a
protein that in humans is encoded by the FOXI3 gene. FOXI3 is a
forkhead box
transcription factor that is expressed in the development of hair and teeth. One of its mutations is a
dominant allele responsible for the
heterozygous Hh hairless trait in dogs. It was identified in 2008.
[5]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000214336 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000055874 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Drögemüller C, Karlsson EK, Hytönen MK, Perloski M, Dolf G, Sainio K, et al. (September 2008). "A mutation in hairless dogs implicates FOXI3 in ectodermal development". Science . 321 (5895): 1462.
Bibcode :
2008Sci...321.1462D .
doi :
10.1126/science.1162525 .
PMID
18787161 .
S2CID
206514824 .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors