From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Hypermethylated in cancer 1 protein is a
protein that in humans is encoded by the HIC1
gene .
[5]
References
Further reading
Chopin V, Leprince D (2006).
"[Chromosome arm 17p13.3: could HIC1 be the one ?]" . Med Sci (Paris) . 22 (1): 54–61.
doi :
10.1051/medsci/200622154 .
PMID
16386221 .
Wales MM, Biel MA, el Deiry W, et al. (1995). "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3". Nat. Med . 1 (6): 570–7.
doi :
10.1038/nm0695-570 .
PMID
7585125 .
S2CID
21993943 .
Fujii H, Biel MA, Zhou W, et al. (1998).
"Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer" . Oncogene . 16 (16): 2159–64.
doi :
10.1038/sj.onc.1201976 .
PMID
9572497 .
Deltour S, Guerardel C, Stehelin D, Leprince D (1999). "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved". Biochim. Biophys. Acta . 1443 (1–2): 230–2.
doi :
10.1016/s0167-4781(98)00219-x .
PMID
9838134 .
Deltour S, Guerardel C, Leprince D (2000).
"Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B" . Proc. Natl. Acad. Sci. U.S.A . 96 (26): 14831–6.
Bibcode :
1999PNAS...9614831D .
doi :
10.1073/pnas.96.26.14831 .
PMC
24733 .
PMID
10611298 .
Guerardel C, Deltour S, Pinte S, et al. (2001).
"Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53" . J. Biol. Chem . 276 (5): 3078–89.
doi :
10.1074/jbc.M008690200 .
PMID
11073960 .
Deltour S, Pinte S, Guérardel C, Leprince D (2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem. Biophys. Res. Commun . 287 (2): 427–34.
doi :
10.1006/bbrc.2001.5624 .
PMID
11554746 .
Deltour S, Pinte S, Guerardel C, et al. (2002).
"The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif" . Mol. Cell. Biol . 22 (13): 4890–901.
doi :
10.1128/MCB.22.13.4890-4901.2002 .
PMC
133903 .
PMID
12052894 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Cardoso C, Leventer RJ, Ward HL, et al. (2003).
"Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3" . Am. J. Hum. Genet . 72 (4): 918–30.
doi :
10.1086/374320 .
PMC
1180354 .
PMID
12621583 .
Rathi A, Virmani AK, Harada K, et al. (2004). "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms". Clin. Cancer Res . 9 (10 Pt 1): 3674–8.
PMID
14506157 .
Waha A, Waha A, Koch A, et al. (2004).
"Epigenetic silencing of the HIC-1 gene in human medulloblastomas" . J. Neuropathol. Exp. Neurol . 62 (11): 1192–201.
doi :
10.1093/jnen/62.11.1192 .
PMID
14656076 .
Lindsey JC, Lusher ME, Anderton JA, et al. (2004).
"Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling" . Carcinogenesis . 25 (5): 661–8.
doi :
10.1093/carcin/bgh055 .
PMID
14688019 .
Pinte S, Guérardel C, Deltour-Balerdi S, et al. (2004).
"Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1" . Oncogene . 23 (22): 4023–31.
doi :
10.1038/sj.onc.1207504 .
PMID
15007385 .
Pinte S, Stankovic-Valentin N, Deltour S, et al. (2004).
"The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties" . J. Biol. Chem . 279 (37): 38313–24.
doi :
10.1074/jbc.M401610200 .
PMID
15231840 .
Chen W, Cooper TK, Zahnow CA, et al. (2004).
"Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis" . Cancer Cell . 6 (4): 387–98.
doi :
10.1016/j.ccr.2004.08.030 .
PMID
15488761 .
Britschgi C, Rizzi M, Grob TJ, et al. (2006). "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1". Oncogene . 25 (14): 2030–9.
doi :
10.1038/sj.onc.1209240 .
PMID
16301995 .
S2CID
27624320 .
Valenta T, Lukas J, Doubravska L, et al. (2006).
"HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies" . EMBO J . 25 (11): 2326–37.
doi :
10.1038/sj.emboj.7601147 .
PMC
1478201 .
PMID
16724116 .
Stankovic-Valentin N, Verger A, Deltour-Balerdi S, et al. (2006). "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP". FEBS J . 273 (13): 2879–90.
doi :
10.1111/j.1742-4658.2006.05301.x .
PMID
16762039 .
S2CID
34249691 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors