Homeobox protein Nkx-2.2 is a
protein that in humans is encoded by the NKX2-2gene.[5][6][7]
Homeobox protein Nkx-2.2 contains a
homeobox domain and may be involved in the
morphogenesis of the central nervous system. This gene is found on chromosome 20 near
NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of
TITF1 and
NKX2-8. The encoded protein is likely to be a nuclear
transcription factor.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Aug 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes. 47 (8): 1356–1358.
doi:
10.2337/diabetes.47.8.1356.
PMID9703340.
^Price M, Lazzaro D, Pohl T, Mattei MG, Rüther U, Olivo JC, Duboule D, Di Lauro R (Feb 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–255.
doi:
10.1016/0896-6273(92)90291-K.
PMID1346742.
S2CID22766848.
Hessabi B, Schmidt I, Walther R (Apr 2000). "The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals". Biochemical and Biophysical Research Communications. 270 (3): 695–700.
doi:
10.1006/bbrc.2000.2491.
PMID10772886.
Wang CC, Brodnicki T, Copeland NG, Jenkins NA, Harvey RP (Jun 2000). "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals". Mammalian Genome. 11 (6): 466–468.
doi:
10.1007/s003350010089.
PMID10818213.
S2CID29283599.