From Wikipedia, the free encyclopedia
Human protein-coding gene
Forkhead box protein P4 is a
protein that in humans is encoded by the FOXP4
gene .
[5]
This gene belongs to subfamily P of the
forkhead box (FOX)
transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific
gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian
oncogenesis . This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different
isoforms .
[5] It also is a major factor in developing
Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications for
COVID-19 pandemic research.
[6]
References
Further reading
Katoh M, Katoh M (2005). "Human FOX gene family (Review)". Int. J. Oncol . 25 (5): 1495–500.
doi :
10.3892/ijo.25.5.1495 .
PMID
15492844 .
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Lu MM, Li S, Yang H, Morrisey EE (2003).
"Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues" . Gene Expr. Patterns . 2 (3–4): 223–8.
doi :
10.1016/S1567-133X(02)00058-3 .
PMID
12617805 .
Teufel A, Wong EA, Mukhopadhyay M, Malik N, Westphal H (2003).
"FoxP4, a novel forkhead transcription factor" . Biochim. Biophys. Acta . 1627 (2–3): 147–52.
doi :
10.1016/S0167-4781(03)00074-5 .
PMID
12818433 .
Lu MM, Li S, Yang H, Morrisey EE (2002).
"Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues" . Mech. Dev . 119 (Suppl 1): S197–202.
doi :
10.1016/S0925-4773(03)00116-3 .
PMID
14516685 .
S2CID
935988 .
Li S, Weidenfeld J, Morrisey EE (2004).
"Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions" . Mol. Cell. Biol . 24 (2): 809–22.
doi :
10.1128/MCB.24.2.809-822.2004 .
PMC
343786 .
PMID
14701752 .
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP (2006).
"Transcriptional genomics associates FOX transcription factors with human heart failure" . Circulation . 114 (12): 1269–76.
doi :
10.1161/CIRCULATIONAHA.106.632430 .
PMID
16952980 .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors