Homeobox protein Hox-C11 is a
protein that in humans is encoded by the HOXC11gene.[5][6][7]
This gene belongs to the
homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in
morphogenesis in all multicellular organisms.
Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on
chromosome 12. The product of this gene binds to a promoter element of the
lactase-phlorizin hydrolase. It also may play a role in early
intestinal development. An alternatively spliced variant encoding a shorter
isoform has been described but its full-length nature has not been determined.[7]
Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–115.
doi:
10.1159/000134320.
PMID8646877.
Flagiello D, Gibaud A, Dutrillaux B, et al. (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Lett. 415 (3): 263–267.
doi:
10.1016/S0014-5793(97)01118-6.
PMID9357979.
S2CID26075369.