From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Cyclic AMP-responsive element-binding protein 3 is a
protein that in humans is encoded by the CREB3
gene .
[5]
[6]
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.
[6]
Interactions
CREB3 has been shown to
interact with
Host cell factor C1 .
[7]
[8]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000107175 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028466 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lu R, Yang P, O'Hare P, Misra V (Sep 1997).
"Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor" . Mol Cell Biol . 17 (9): 5117–26.
doi :
10.1128/MCB.17.9.5117 .
PMC
232362 .
PMID
9271389 .
^
a
b
"Entrez Gene: CREB3 cAMP responsive element binding protein 3" .
^ Lu R, Yang P, Padmakumar S, Misra V (Aug 1998).
"The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF" . J. Virol . 72 (8): 6291–7.
doi :
10.1128/JVI.72.8.6291-6297.1998 .
ISSN
0022-538X .
PMC
109766 .
PMID
9658067 .
^ Freiman RN, Herr W (Dec 1997).
"Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP" . Genes Dev . 11 (23): 3122–7.
doi :
10.1101/gad.11.23.3122 .
ISSN
0890-9369 .
PMC
316754 .
PMID
9389645 .
Further reading
Freiman RN, Herr W (1998).
"Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP" . Genes Dev . 11 (23): 3122–7.
doi :
10.1101/gad.11.23.3122 .
PMC
316754 .
PMID
9389645 .
Lu R, Yang P, Padmakumar S, Misra V (1998).
"The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF" . J. Virol . 72 (8): 6291–7.
doi :
10.1128/JVI.72.8.6291-6297.1998 .
PMC
109766 .
PMID
9658067 .
Lu R, Misra V (2000).
"Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency" . J. Virol . 74 (2): 934–43.
doi :
10.1128/JVI.74.2.934-943.2000 .
PMC
111614 .
PMID
10623756 .
Mahajan SS, Wilson AC (2000).
"Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP" . Mol. Cell. Biol . 20 (3): 919–28.
doi :
10.1128/MCB.20.3.919-928.2000 .
PMC
85209 .
PMID
10629049 .
Jin DY, Wang HL, Zhou Y, et al. (2000).
"Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation" . EMBO J . 19 (4): 729–40.
doi :
10.1093/emboj/19.4.729 .
PMC
305611 .
PMID
10675342 .
Luciano RL, Wilson AC (2000).
"N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif" . Proc. Natl. Acad. Sci. U.S.A . 97 (20): 10757–62.
Bibcode :
2000PNAS...9710757L .
doi :
10.1073/pnas.190062797 .
PMC
27096 .
PMID
10984507 .
Raggo C, Rapin N, Stirling J, et al. (2002).
"Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis" . Mol. Cell. Biol . 22 (16): 5639–49.
doi :
10.1128/MCB.22.16.5639-5649.2002 .
PMC
133973 .
PMID
12138176 .
Mahajan SS, Little MM, Vazquez R, Wilson AC (2003).
"Interaction of HCF-1 with a cellular nuclear export factor" . J. Biol. Chem . 277 (46): 44292–9.
doi :
10.1074/jbc.M205440200 .
PMC
4291127 .
PMID
12235138 .
Luciano RL, Wilson AC (2002).
"An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP" . Proc. Natl. Acad. Sci. U.S.A . 99 (21): 13403–8.
Bibcode :
2002PNAS...9913403L .
doi :
10.1073/pnas.202200399 .
PMC
129685 .
PMID
12271126 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ko J, Jang SW, Kim YS, et al. (2004).
"Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines" . FASEB J . 18 (7): 890–2.
doi :
10.1096/fj.03-0867fje .
PMID
15001559 .
S2CID
24742296 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Misra V, Rapin N, Akhova O, et al. (2005).
"Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman" . J. Biol. Chem . 280 (15): 15257–66.
doi :
10.1074/jbc.M500728200 .
PMID
15705566 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Liang G, Audas TE, Li Y, et al. (2007).
"Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element" . Mol. Cell. Biol . 26 (21): 7999–8010.
doi :
10.1128/MCB.01046-06 .
PMC
1636730 .
PMID
16940180 .
Blot G, Lopez-Vergès S, Treand C, et al. (2007). "Luman, a new partner of HIV-1 TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR". J. Mol. Biol . 364 (5): 1034–47.
doi :
10.1016/j.jmb.2006.09.080 .
PMID
17054986 .
Jang SW, Kim YS, Lee YH, Ko J (2007). "Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines". J. Cell. Physiol . 211 (3): 630–7.
doi :
10.1002/jcp.20968 .
PMID
17192849 .
S2CID
40274182 .
Jang SW, Kim YS, Kim YR, et al. (2007).
"Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1" . J. Biol. Chem . 282 (15): 11092–100.
doi :
10.1074/jbc.M607962200 .
PMID
17296613 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors