From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Homeobox protein Nkx-6.1 is a
protein that in humans is encoded by the NKX6-1
gene .
[5]
[6]
Function
In the
pancreas , NKX6.1 is required for the development of
beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000163623 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000035187 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics . 40 (2): 367–70.
doi :
10.1006/geno.1996.4568 .
PMID
9119408 .
^
a
b
"Entrez Gene: NK6 homeobox 1" .
Further reading
Schisler JC, Fueger PT, Babu DA, et al. (2008).
"Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1" . Mol. Cell. Biol . 28 (10): 3465–76.
doi :
10.1128/MCB.01791-07 .
PMC
2423154 .
PMID
18347054 .
Hori Y, Gu X, Xie X, Kim SK (2005).
"Differentiation of insulin-producing cells from human neural progenitor cells" . PLOS Med . 2 (4): e103.
doi :
10.1371/journal.pmed.0020103 .
PMC
1087208 .
PMID
15839736 .
Jørgensen MC, Vestergírd Petersen H, Ericson J, et al. (1999).
"Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1" . FEBS Lett . 461 (3): 287–94.
doi :
10.1016/S0014-5793(99)01436-2 .
PMID
10567713 .
S2CID
1735843 .
Iype T, Taylor DG, Ziesmann SM, et al. (2004).
"The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1" . Mol. Endocrinol . 18 (6): 1363–75.
doi :
10.1210/me.2004-0006 .
PMID
15056733 .
Yokoi N, Kanamori M, Horikawa Y, et al. (2006).
"Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects" . Diabetes . 55 (8): 2379–86.
doi :
10.2337/db05-1203 .
PMID
16873704 .
Zhu S, Xia HH, Yang Y, et al. (2009). "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia". Dig. Dis. Sci . 54 (5): 996–1002.
doi :
10.1007/s10620-008-0459-8 .
PMID
18754095 .
S2CID
25173708 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors