From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Non-histone chromosomal protein HMG-14 is a
protein that in humans is encoded by the HMGN1
gene .
[5]
[6]
[7]
Function
Chromosomal protein HMG14 and its close analog
HMG17 (MIM 163910) bind to the inner side of the
nucleosomal DNA , potentially altering the interaction between the DNA and the
histone octamer . The 2 proteins may be involved in the process that maintains transcribable genes in a unique
chromatin conformation.
[8] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.
[7]
Interactions
HMGN1 has been shown to
interact with
YWHAZ .
[9]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000205581 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000040681 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Landsman D, Srikantha T, Westermann R, Bustin M (Dec 1986).
"Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family" . The Journal of Biological Chemistry . 261 (34): 16082–6.
doi :
10.1016/S0021-9258(18)66680-3 .
PMID
3782107 .
^ Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Feb 1989).
"Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family" . The Journal of Biological Chemistry . 264 (6): 3421–7.
doi :
10.1016/S0021-9258(18)94084-6 .
PMID
2563381 .
^
a
b
"Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1" .
^ Martínez de Paz A, Ausió J (2016).
"HMGNs: The enhancer charmers" . BioEssays . 38 (3): 226–31.
doi :
10.1002/bies.201500157 .
PMID
26709929 .
S2CID
24768724 .
^ Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002).
"Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins" . Molecular and Cellular Biology . 22 (19): 6809–19.
doi :
10.1128/MCB.22.19.6809-6819.2002 .
PMC
134047 .
PMID
12215538 .
Further reading
Pash J, Popescu N, Matocha M, Rapoport S, Bustin M (May 1990).
"Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16" . Proceedings of the National Academy of Sciences of the United States of America . 87 (10): 3836–40.
Bibcode :
1990PNAS...87.3836P .
doi :
10.1073/pnas.87.10.3836 .
PMC
53998 .
PMID
2140193 .
Leffak M, Trempe JP (Jul 1985).
"Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus" . Nucleic Acids Research . 13 (13): 4853–69.
doi :
10.1093/nar/13.13.4853 .
PMC
321831 .
PMID
4022776 .
Postnikov YV, Trieschmann L, Rickers A, Bustin M (Sep 1995).
"Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores" . Journal of Molecular Biology . 252 (4): 423–32.
doi :
10.1006/jmbi.1995.0508 .
PMID
7563062 .
Ding HF, Rimsky S, Batson SC, Bustin M, Hansen U (Aug 1994). "Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14". Science . 265 (5173): 796–9.
Bibcode :
1994Sci...265..796D .
doi :
10.1126/science.8047885 .
PMID
8047885 .
Pash JM, Alfonso PJ, Bustin M (Jun 1993).
"Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation" . The Journal of Biological Chemistry . 268 (18): 13632–8.
doi :
10.1016/S0021-9258(19)38695-8 .
PMID
8514795 .
Bustin M, Alfonso PJ, Pash JM, Ward JM, Gearhart JD, Reeves RH (Dec 1995).
"Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin" . DNA and Cell Biology . 14 (12): 997–1005.
doi :
10.1089/dna.1995.14.997 .
PMID
8534374 .
Hock R, Scheer U, Bustin M (Dec 1998).
"Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport" . The Journal of Cell Biology . 143 (6): 1427–36.
doi :
10.1083/jcb.143.6.1427 .
PMC
2132996 .
PMID
9852141 .
Louie DF, Gloor KK, Galasinski SC, Resing KA, Ahn NG (Jan 2000).
"Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry" . Protein Science . 9 (1): 170–9.
doi :
10.1110/ps.9.1.170 .
PMC
2144438 .
PMID
10739259 .
Bergel M, Herrera JE, Thatcher BJ, Prymakowska-Bosak M, Vassilev A, Nakatani Y, Martin B, Bustin M (Apr 2000).
"Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes" . The Journal of Biological Chemistry . 275 (15): 11514–20.
doi :
10.1074/jbc.275.15.11514 .
PMID
10753971 .
Prymakowska-Bosak M, Misteli T, Herrera JE, Shirakawa H, Birger Y, Garfield S, Bustin M (Aug 2001).
"Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin" . Molecular and Cellular Biology . 21 (15): 5169–78.
doi :
10.1128/MCB.21.15.5169-5178.2001 .
PMC
87241 .
PMID
11438671 .
Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002).
"Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins" . Molecular and Cellular Biology . 22 (19): 6809–19.
doi :
10.1128/MCB.22.19.6809-6819.2002 .
PMC
134047 .
PMID
12215538 .
Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS (Jun 2003).
"MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14" . The EMBO Journal . 22 (11): 2788–97.
doi :
10.1093/emboj/cdg273 .
PMC
156769 .
PMID
12773393 .
Zou Y, Jiang X, Wang Y (May 2004). "Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells". Biochemistry . 43 (20): 6322–9.
doi :
10.1021/bi0362828 .
PMID
15147216 .
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .