Transcription factor SOX-11 is a
protein that in humans is encoded by the SOX11gene.[5][6][7]
Function
This intronless gene encodes a member of the group C SOX (
SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.[7][8] Tuj1 and Tead2 are suggested as direct target of Sox11.[9][10][11]
Clinical aspect
Lymphocyte staining for SOX11
immunohistochemistry indicates
mantle cell lymphoma (cyclin D1 positive and negative) rather than other mature lymphoid neoplasms or normal lymphocytes.[12]
^Haslinger A, Schwarz TJ, Covic M, Lie DC (Jun 2009). "Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis". The European Journal of Neuroscience. 29 (11): 2103–14.
doi:
10.1111/j.1460-9568.2009.06768.x.
PMID19490090.
S2CID42742018.
^Anna Dusenbery, M.D., Mark R. Wick, M.D.
"Stains & CD markers - SOX11". Pathology Outlines.{{
cite web}}: CS1 maint: multiple names: authors list (
link) Topic Completed: 1 January 2018. Minor changes: 12 August 2021
Wilson M, Koopman P (Aug 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development. 12 (4): 441–6.
doi:
10.1016/S0959-437X(02)00323-4.
PMID12100890.
DesGroseilliers M, Fortin F, Lemyre E, Lemieux N (2006). "Complex mosaicism in sex reversed SRY+ male twins". Cytogenetic and Genome Research. 112 (1–2): 176–9.
doi:
10.1159/000087532.
PMID16276109.
S2CID43826181.
External links
Overview of all the structural information available in the
PDB for
UniProt: P35716 (Human Transcription factor SOX-11) at the
PDBe-KB.