Bicaudal D cargo adaptor 2 is a
protein that in humans is encoded by the BICD2gene.[5][6]
This gene is one of two human
homologs of
Drosophila bicaudal-D and a member of the
Bicoid family. It has been implicated in
dynein-mediated, minus end-directed
motility along
microtubules. It has also been reported to be a
phosphorylation target of NIMA related
kinase 8. Two alternative splice variants have been described.[6]
Mutations in BICD2 are associated with spinal muscular atrophy with lower extremity predominance
type 2A and
type 2B.
Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, et al. (2003). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat. Cell Biol. 4 (12): 986–92.
doi:
10.1038/ncb891.
PMID12447383.
S2CID7953140.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72.
doi:
10.1021/ac035352d.
PMID15144186.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101.
doi:
10.1038/nbt1046.
PMID15592455.
S2CID7200157.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.