From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Forkhead box O6 is a
protein that in humans is encoded by the FOXO6
gene .
[5]
FoxO6 is expressed in the liver, skeletal muscle, and the
hippocampus of the brain.
[6] In the liver, FoxO6 normally promotes
gluconeogenesis in the fasted state, but
insulin blocks Fox06 upon feeding.
[6] In a condition of
insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.
[6]
References
Further reading
Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP (September 2003).
"FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics" . The Journal of Biological Chemistry . 278 (38): 35959–67.
doi :
10.1074/jbc.M302804200 .
PMID
12857750 .
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010).
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score" . Molecular Medicine . 16 (7–8): 247–53.
doi :
10.2119/molmed.2009.00159 .
PMC
2896464 .
PMID
20379614 .
Kleindorp R, Flachsbart F, Puca AA, Malovini A, Schreiber S, Nebel A (August 2011).
"Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans" . Aging Cell . 10 (4): 622–8.
doi :
10.1111/j.1474-9726.2011.00698.x .
PMID
21388494 .
Tzivion G, Dobson M, Ramakrishnan G (November 2011).
"FoxO transcription factors; Regulation by AKT and 14-3-3 proteins" . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1813 (11): 1938–45.
doi :
10.1016/j.bbamcr.2011.06.002 .
PMID
21708191 .
Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH (November 2011).
"FoxO6 integrates insulin signaling with gluconeogenesis in the liver" . Diabetes . 60 (11): 2763–74.
doi :
10.2337/db11-0548 .
PMC
3198083 .
PMID
21940782 .
Kim DH, Zhang T, Lee S, Dong HH (September 2013).
"FoxO6 in glucose metabolism (FoxO6)" . Journal of Diabetes . 5 (3): 233–40.
doi :
10.1111/1753-0407.12027 .
PMC
3657578 .
PMID
23324123 .
Qinyu L, Long C, Zhen-dong D, Min-min S, Wei-ze W, Wei-ping Y, Cheng-hong P (July 2013).
"FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc" . FEBS Letters . 587 (14): 2105–11.
doi :
10.1016/j.febslet.2013.05.027 .
PMID
23714368 .
S2CID
38064268 .