From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
T-cell acute lymphocytic leukemia 2 , also known as TAL2 , is a
protein which in humans is encoded by the TAL2
gene .
[5]
[6]
Function
TAL2 is a member of the
basic helix-loop-helix family of
transcription factors .
[7]
Clinical significance
Tumor-specific alterations of the TAL2 gene occurs in some patients with
T-cell acute lymphoblastic leukemia (T-ALL).
[6]
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000186051 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028417 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2" .
^
a
b Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991).
"TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia" . Proc. Natl. Acad. Sci. U.S.A . 88 (24): 11416–20.
Bibcode :
1991PNAS...8811416X .
doi :
10.1073/pnas.88.24.11416 .
PMC
53146 .
PMID
1763056 .
^ Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol . 4 (6): 341–7.
PMID
8142619 .
^ Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet . 33 (3): 342–4.
doi :
10.1038/ng1092 .
PMID
12567187 .
S2CID
20213008 .
Further reading
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Humphray SJ, Oliver K, Hunt AR, et al. (2004).
"DNA sequence and analysis of human chromosome 9" . Nature . 429 (6990): 369–74.
Bibcode :
2004Natur.429..369H .
doi :
10.1038/nature02465 .
PMC
2734081 .
PMID
15164053 .
Marculescu R, Vanura K, Le T, et al. (2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet . 33 (3): 342–4.
doi :
10.1038/ng1092 .
PMID
12567187 .
S2CID
20213008 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Xia Y, Hwang LY, Cobb MH, Baer R (1994). "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity". Oncogene . 9 (5): 1437–46.
PMID
8152805 .
Wadman I, Li J, Bash RO, et al. (1994).
"Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia" . EMBO J . 13 (20): 4831–9.
doi :
10.1002/j.1460-2075.1994.tb06809.x .
PMC
395422 .
PMID
7957052 .
Xia Y, Brown L, Yang CY, et al. (1992).
"TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia" . Proc. Natl. Acad. Sci. U.S.A . 88 (24): 11416–20.
Bibcode :
1991PNAS...8811416X .
doi :
10.1073/pnas.88.24.11416 .
PMC
53146 .
PMID
1763056 .
Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992).
"T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein" . Blood . 80 (11): 2858–66.
doi :
10.1182/blood.V80.11.2858.bloodjournal80112858 .
PMID
1450410 .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors