From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Transcription factor RFX4 is a
protein that in humans is encoded by the RFX4
gene .
[5]
[6]
[7]
This gene is a member of the regulatory factor X gene family, which encodes
transcription factors that contain a highly conserved winged helix DNA
binding domain . The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional
repressor rather than a transcriptional activator. Three transcript variants encoding different
isoforms have been described for this gene.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000111783 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020037 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Emery P, Durand B, Mach B, Reith W (May 1996).
"RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom" . Nucleic Acids Res . 24 (5): 803–7.
doi :
10.1093/nar/24.5.803 .
PMC
145730 .
PMID
8600444 .
^ Morotomi-Yano K, Yano K, Saito H, Sun Z, Iwama A, Miki Y (Jan 2002).
"Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members" . J Biol Chem . 277 (1): 836–42.
doi :
10.1074/jbc.M108638200 .
PMID
11682486 .
^
a
b
"Entrez Gene: RFX4 regulatory factor X, 4 (influences HLA class II expression)" .
Further reading
Dotzlaw H, Alkhalaf M, Murphy LC (1992).
"Characterization of estrogen receptor variant mRNAs from human breast cancers" . Mol. Endocrinol . 6 (5): 773–85.
doi :
10.1210/mend.6.5.1603086 .
PMID
1603086 .
S2CID
25208340 .
Reith W, Ucla C, Barras E, et al. (1994).
"RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins" . Mol. Cell. Biol . 14 (2): 1230–44.
doi :
10.1128/mcb.14.2.1230 .
PMC
358479 .
PMID
8289803 .
Gajiwala KS, Chen H, Cornille F, et al. (2000). "Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding". Nature . 403 (6772): 916–21.
Bibcode :
2000Natur.403..916G .
doi :
10.1038/35002634 .
PMID
10706293 .
S2CID
4425783 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Blackshear PJ, Graves JP, Stumpo DJ, et al. (2003).
"Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4" . Development . 130 (19): 4539–52.
doi :
10.1242/dev.00661 .
PMID
12925582 .
Araki R, Takahashi H, Fukumura R, et al. (2004).
"Restricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus" . J. Biol. Chem . 279 (11): 10237–42.
doi :
10.1074/jbc.M312761200 .
PMID
14701801 .
Glaser B, Kirov G, Bray NJ, et al. (2005).
"Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4" . Mol. Psychiatry . 10 (10): 920–7.
doi :
10.1038/sj.mp.4001689 .
PMID
15940297 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Matsushita H, Uenaka A, Ono T, et al. (2006).
"Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients" (PDF) . Cancer Sci . 96 (11): 801–9.
doi :
10.1111/j.1349-7006.2005.00112.x .
PMID
16271074 .
S2CID
25967004 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors