From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Transcription cofactor HES-6 is a
protein that in humans is encoded by the HES6
gene .
[5]
[6]
Interactions
HES6 has been shown to
interact with
TLE1 .
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000144485 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000067071 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development . 127 (13): 2933–43.
doi :
10.1242/dev.127.13.2933 .
PMID
10851137 .
^
"Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)" .
^ Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001).
"HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program" . J. Cell Biol . 154 (6): 1161–71.
doi :
10.1083/jcb.200104058 .
PMC
2150829 .
PMID
11551980 .
Further reading
Bech P, Bolwig TG, Dein E, Jacobsen O, Gram LF (1975). "Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale".
Acta Psychiatr Scand . 52 (1): 1–6.
doi :
10.1111/j.1600-0447.1975.tb00017.x .
PMID
1155198 .
S2CID
7793095 .
Vasiliauskas D, Stern CD (2000).
"Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors" . Mech. Dev . 98 (1–2): 133–7.
doi :
10.1016/S0925-4773(00)00443-3 .
PMID
11044617 .
S2CID
15528953 .
Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (2001).
"HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program" . J. Cell Biol . 154 (6): 1161–71.
doi :
10.1083/jcb.200104058 .
PMC
2150829 .
PMID
11551980 .
Swearingen ML, Sun D, Bourner M, Weinstein EJ (2003). "Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array". Cancer Lett . 198 (2): 229–39.
doi :
10.1016/S0304-3835(03)00313-6 .
PMID
12957362 .
Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S (2003).
"Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms" . Mol. Cell. Biol . 23 (19): 6922–35.
doi :
10.1128/MCB.23.19.6922-6935.2003 .
PMC
193938 .
PMID
12972610 .
Kang SA, Seol JH, Kim J (2005). "The conserved WRPW motif of Hes6 mediates proteasomal degradation". Biochem. Biophys. Res. Commun . 332 (1): 33–6.
doi :
10.1016/j.bbrc.2005.04.089 .
PMID
15896295 .
Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F (2007).
"HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion" . Biochem. Biophys. Res. Commun . 355 (2): 331–7.
doi :
10.1016/j.bbrc.2007.01.153 .
PMC
1852427 .
PMID
17300753 .
Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D (2007). "Impaired expression of Notch signaling genes in aged human skeletal muscle". J. Gerontol. A Biol. Sci. Med. Sci . 62 (1): 9–17.
CiteSeerX
10.1.1.499.7911 .
doi :
10.1093/gerona/62.1.9 .
PMID
17301032 .
Scheffer D, Sage C, Corey DP, Pingault V (2007).
"Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells" . FEBS Lett . 581 (24): 4651–6.
doi :
10.1016/j.febslet.2007.08.059 .
PMID
17826772 .
S2CID
13986512 .
External links
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .