Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Dlx3 transcription is mediated through
Wnt, and colocalization of Dlx3 with
phospho-
SMAD1/
5/
8 is involved in the regulation of transcription by
BMP signaling.[7] Dlx3 transcription is also induced by
BMP-2 through
transactivation with
SMAD1 and
SMAD4.[8]
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a
homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members,
DLX1-
DLX6. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of
chromosome 17.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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