From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a
protein that in humans is encoded by the BACH2
gene .
[5]
[6]
[7] It contains a
BTB/POZ domain at its
N-terminus which forms a disulphide-linked dimer
[8] and a
bZip_Maf domain at the C-terminus.
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000112182 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000040270 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (August 2000).
"Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15" . Oncogene . 19 (33): 3739–49.
doi :
10.1038/sj.onc.1203716 .
PMID
10949928 .
^ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (November 2003).
"B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs" . Blood . 102 (9): 3317–22.
doi :
10.1182/blood-2002-12-3656 .
PMID
12829606 .
^
"Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2" .
^ Rosbrook GO, Stead MA, Carr SB, Wright SC (January 2012).
"The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond" (PDF) . Acta Crystallographica Section D . 68 (Pt 1): 26–34.
Bibcode :
2012AcCrD..68...26R .
doi :
10.1107/S0907444911048335 .
PMID
22194330 .
Further reading
Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, Yamamoto M, Igarashi K (November 1996).
"Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site" . Molecular and Cellular Biology . 16 (11): 6083–95.
doi :
10.1128/mcb.16.11.6083 .
PMC
231611 .
PMID
8887638 .
Kobayashi A, Yamagiwa H, Hoshino H, Muto A, Sato K, Morita M, Hayashi N, Yamamoto M, Igarashi K (March 2000).
"A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain" . Molecular and Cellular Biology . 20 (5): 1733–46.
doi :
10.1128/MCB.20.5.1733-1746.2000 .
PMC
85356 .
PMID
10669750 .
Hoshino H, Kobayashi A, Yoshida M, Kudo N, Oyake T, Motohashi H, Hayashi N, Yamamoto M, Igarashi K (May 2000).
"Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element" . The Journal of Biological Chemistry . 275 (20): 15370–6.
doi :
10.1074/jbc.275.20.15370 .
PMID
10809773 .
Vieira SA, Deininger MW, Sorour A, Sinclair P, Foroni L, Goldman JM, Melo JV (December 2001). "Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene". Genes, Chromosomes & Cancer . 32 (4): 353–63.
doi :
10.1002/gcc.1200 .
PMID
11746976 .
S2CID
21020332 .
Muto A, Tashiro S, Tsuchiya H, Kume A, Kanno M, Ito E, Yamamoto M, Igarashi K (June 2002).
"Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies" . The Journal of Biological Chemistry . 277 (23): 20724–33.
doi :
10.1074/jbc.M112003200 .
PMID
11923289 .
Takakuwa T, Luo WJ, Ham MF, Sakane-Ishikawa F, Wada N, Aozasa K (March 2004).
"Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression" . The American Journal of Pathology . 164 (3): 967–74.
doi :
10.1016/S0002-9440(10)63184-7 .
PMC
1614712 .
PMID
14982850 .
Tashiro S, Muto A, Tanimoto K, Tsuchiya H, Suzuki H, Hoshino H, Yoshida M, Walter J, Igarashi K (April 2004).
"Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2" . Molecular and Cellular Biology . 24 (8): 3473–84.
doi :
10.1128/MCB.24.8.3473-3484.2004 .
PMC
381671 .
PMID
15060166 .
Motamed-Khorasani A, Jurisica I, Letarte M, Shaw PA, Parkes RK, Zhang X, Evangelou A, Rosen B, Murphy KJ, Brown TJ (January 2007). "Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression". Oncogene . 26 (2): 198–214.
doi :
10.1038/sj.onc.1209773 .
PMID
16832351 .
S2CID
23262017 .
Yoshida C, Yoshida F, Sears DE, Hart SM, Ikebe D, Muto A, Basu S, Igarashi K, Melo JV (February 2007).
"Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1" . Blood . 109 (3): 1211–9.
doi :
10.1182/blood-2005-12-040972 .
PMID
17018862 .
S2CID
10475263 .
Ono A, Kono K, Ikebe D, Muto A, Sun J, Kobayashi M, Ueda K, Melo JV, Igarashi K, Tashiro S (January 2007). "Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells". Genes, Chromosomes & Cancer . 46 (1): 67–74.
doi :
10.1002/gcc.20390 .
PMID
17044046 .
S2CID
13276741 .
Ikeda T, Shibata J, Yoshimura K, Koito A, Matsushita S (March 2007).
"Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy" . The Journal of Infectious Diseases . 195 (5): 716–25.
doi :
10.1086/510915 .
PMID
17262715 .
Hoshino H, Nishino TG, Tashiro S, Miyazaki M, Ohmiya Y, Igarashi K, Horinouchi S, Yoshida M (May 2007). "Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression". Journal of Biochemistry . 141 (5): 719–27.
CiteSeerX
10.1.1.326.4123 .
doi :
10.1093/jb/mvm073 .
PMID
17383980 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors