From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
GLIS family zinc finger 2 also known as GLIS2 is a human
gene .
[1]
[2]
Function
The
protein encoded by this gene is a
Kruppel-like
transcription factor which functions depending on the gene and promoter context as an activator or repressor of
gene transcription .
[2] GLIS2 plays a role in kidney development and
neurogenesis .
[2]
Glis2
knockout mice display decreased size and weight. The kidneys in these mice show progressive kidney atrophy and display symptoms similar to human
nephronophthisis . Glis2 plays an essential role in the maintenance of renal tissue through prevention of
apoptosis and
fibrosis .
[3]
Clinical significance
Mutations in the GLIS2 gene are associated with
nephronophthisis .
[3]
References
^ Zhang F, Jetten AM (December 2001). "Genomic structure of the gene encoding the human GLI-related, Krüppel-like zinc finger protein GLIS2". Gene . 280 (1–2): 49–57.
doi :
10.1016/S0378-1119(01)00764-8 .
PMID
11738817 .
^
a
b
c Zhang F, Nakanishi G, Kurebayashi S, Yoshino K, Perantoni A, Kim YS, Jetten AM (March 2002).
"Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis" . The Journal of Biological Chemistry . 277 (12): 10139–49.
doi :
10.1074/jbc.M108062200 .
PMID
11741991 .
^
a
b AAttanasio M, Uhlenhaut NH, Sousa VH, O'Toole JF, Otto E, Anlag K, Klugmann C, Treier AC, Helou J, Sayer JA, Seelow D, Nürnberg G, Becker C, Chudley AE, Nürnberg P, Hildebrandt F, Treier M (August 2007). "Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis". Nature Genetics . 39 (8): 1018–24.
doi :
10.1038/ng2072 .
PMID
17618285 .
S2CID
6394185 .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors