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Class of proteins
NKX-homeodomain factors are a family of
homeodomain
transcription factors that are critical regulators of organ
development .
[1]
Human genes that encode NKX-homeodomain factors include:
References
^ Stanfel MN, Moses KA, Schwartz RJ, Zimmer WE (2005). "Regulation of organ development by the NKX-homeodomain factors: an NKX code". Cell. Mol. Biol. (Noisy-le-grand) . Suppl 51: OL785–99.
PMID
16405855 .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors