From Wikipedia, the free encyclopedia
Protein family
The aryl-hydrocarbon receptor repressor also known as AHRR is a human
gene .
[1]
Function
Dioxins and dioxin-like compounds are
teratogens that exert their effects through the
aryl hydrocarbon receptor (AhR) in conjunction with the
receptor 's binding partner,
aryl hydrocarbon receptor nuclear translocator (ARNT). The
protein encoded by this gene represses
signal transduction by the AhR by competing with the arylhydrocarbon receptor for binding to the ARNT.
[2] Expression of the
repressor is stimulated by the receptor/translocator
heterodimer , thereby regulating receptor function through a
negative feedback mechanism. In addition, the encoded protein can bind to
nuclear factor-kappa B .
The AhRR gene may act as a tumor suppressor.
[3]
[4]
Tissue distribution
The expression of AhRR is high in testis, lung, ovary, spleen and pancreas in adults, whereas expression is low in all tissues in fetuses.
[5]
References
^ Baba T, Mimura J, Gradin K, Kuroiwa A, Watanabe T, Matsuda Y, Inazawa J, Sogawa K, Fujii-Kuriyama Y (August 2001).
"Structure and expression of the Ah receptor repressor gene" . J. Biol. Chem . 276 (35): 33101–10.
doi :
10.1074/jbc.M011497200 .
PMID
11423533 .
^ Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, Hahn ME (February 2008).
"Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator" . Mol. Pharmacol . 73 (2): 387–98.
doi :
10.1124/mol.107.040204 .
PMC
3263532 .
PMID
18000031 .
^ Zudaire E, Cuesta N, Murty V, Woodson K, Adams L, Gonzalez N, Martínez A, Narayan G, Kirsch I, Franklin W, Hirsch F, Birrer M, Cuttitta F (February 2008).
"The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers" . J. Clin. Invest . 118 (2): 640–50.
doi :
10.1172/JCI30024 .
PMC
2157559 .
PMID
18172554 .
^ Kanno Y, Takane Y, Izawa T, Nakahama T, Inouye Y (June 2006).
"The Inhibitory Effect of Aryl Hydrocarbon Receptor Repressor (AhRR) on the Growth of Human Breast Cancer MCF-7 Cells" . Biol. Pharm. Bull . 29 (6): 1254–7.
doi :
10.1248/bpb.29.1254 .
PMID
16755028 .
^ Yamamoto J, Ihara K, Nakayama H, Hikino S, Satoh K, Kubo N, Iida T, Fujii Y, Hara T (January 2004). "Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells". Life Sci . 74 (8): 1039–49.
doi :
10.1016/j.lfs.2003.07.022 .
PMID
14672759 .
External links
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors