From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
CCAAT/enhancer-binding protein gamma (C/EBPγ) is a
protein that in humans is encoded by the CEBPG
gene .
[5]
[6] This gene has no
introns .
The
C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the
bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a
leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins,
C/EBPα ,
C/EBPβ , C/EBPγ,
C/EBPδ ,
C/EBPζ , and
C/EBPε , that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with
Fos to bind the positive regulatory element-I (PRE-I) enhancer elements.
[6]
[7]
C/EBPγ forms heterodimer with
ATF4 for transcriptional activation of target genes in
autophagy specifically to
amino acid starvation .
[8]
C/EBPγ along with its regulator, the trauma-induced transcription factor
EGR1 , plays an important role in the development of
chronic pain and
mechanical hypersensitivity after some types of
injury or
surgery .
[9]
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000153879 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000056216 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Williams SC, Cantwell CA, Johnson PF (Oct 1991).
"A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro" . Genes Dev . 5 (9): 1553–67.
doi :
10.1101/gad.5.9.1553 .
PMID
1884998 .
^
a
b
"Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma" .
^ Davydov, Ilia V.; Bohmann, Dirk; Krammer, Peter H.; Li-Weber, Min (1995).
"Cloning of the cDNA encoding human C/EBPγ, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter" . Gene . 161 (2): 271–275.
doi :
10.1016/0378-1119(95)00271-7 .
PMID
7665092 .
^ Kim, Dongha; Kim, Junil; Yu, Young Suk; Kim, Yong Ryoul; Baek, Sung Hee; Won, Kyoung-Jae (Jul 2022).
"Systemic approaches using single cell transcriptome reveal that C/EBPγ regulates autophagy under amino acid starved condition" . Nucleic Acids Research . 50 (13): 7298–7309.
doi :
10.1093/nar/gkac593 .
PMC
9303372 .
PMID
35801910 .
^ Mamet, Julien; Klukinov, Michael; Yaksh, Tony L.; Malkmus, Shelle A.; Williams, Samantha; Harris, Scott; Manning, Donald C.; Taylor, Bradley K.; Donahue, Renee R.; Porreca, Frank; Xie, Jennifer Y.; Oyarzo, Janice; Brennan, Timothy J.; Subieta, Alberto; Schmidt, William K.; Yeomans, David C. (2014).
"Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury" . Pain . 155 (2): 322–333.
doi :
10.1016/j.pain.2013.10.015 .
PMID
24145208 .
S2CID
29286007 .
^ Stephens, Kimberly E.; Moore, Cedric; Vinson, David A.; White, Bryan E.; Renfro, Zachary; Zhou, Weiqiang; Ji, Zhicheng; Ji, Hongkai; Zhu, Heng; Guan, Yun; Taverna, Sean D. (2022).
"Identification of regulatory elements in primary sensory neurons involved in neuropathic pain" .
doi :
10.1101/2022.09.09.507328 .
S2CID
252217024 .
Further reading
Nishizawa M, Nagata S (1992). "cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein". FEBS Lett . 299 (1): 36–8.
doi :
10.1016/0014-5793(92)80094-W .
PMID
1371974 .
S2CID
34097395 .
Thomassin H, Hamel D, Bernier D, et al. (1992).
"Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma" . Nucleic Acids Res . 20 (12): 3091–8.
doi :
10.1093/nar/20.12.3091 .
PMC
312443 .
PMID
1377818 .
Nishizawa M, Wakabayashi-Ito N, Nagata S (1991).
"Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1" . FEBS Lett . 282 (1): 95–7.
doi :
10.1016/0014-5793(91)80452-9 .
PMID
1709121 .
S2CID
948618 .
Cooper C, Henderson A, Artandi S, et al. (1996).
"Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators" . Nucleic Acids Res . 23 (21): 4371–7.
doi :
10.1093/nar/23.21.4371 .
PMC
307392 .
PMID
7501458 .
Martin ML, Lieberman PM, Curran T (1996).
"Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF" . Mol. Cell. Biol . 16 (5): 2110–8.
doi :
10.1128/mcb.16.5.2110 .
PMC
231198 .
PMID
8628277 .
Gao H, Parkin S, Johnson PF, Schwartz RC (2002).
"C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters" . J. Biol. Chem . 277 (41): 38827–37.
doi :
10.1074/jbc.M206224200 .
PMID
12177065 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Hattori T, Ohoka N, Inoue Y, et al. (2003). "C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer". Oncogene . 22 (9): 1273–80.
doi :
10.1038/sj.onc.1206204 .
PMID
12618752 .
S2CID
1351748 .
Newman JR, Keating AE (2003).
"Comprehensive identification of human bZIP interactions with coiled-coil arrays" . Science . 300 (5628): 2097–101.
Bibcode :
2003Sci...300.2097N .
doi :
10.1126/science.1084648 .
PMID
12805554 .
S2CID
36715183 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Mullins DN, Crawford EL, Khuder SA, et al. (2006).
"CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma" . BMC Cancer . 5 : 141.
doi :
10.1186/1471-2407-5-141 .
PMC
1310620 .
PMID
16255782 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors