From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
DIDO1
Identifiers
Aliases
DIDO1 , BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8, death inducer-obliterator 1External IDs
OMIM :
604140
MGI :
1344352
HomoloGene :
34139
GeneCards :
DIDO1
Wikidata
Death-inducer obliterator 1 is a
protein that in humans is encoded by the DIDO1
gene .
[5]
[6]
Function
Apoptosis , a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000101191 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000038914 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, Martinez-A C (Aug 1999).
"DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development" . Proc Natl Acad Sci U S A . 96 (14): 7992–7.
Bibcode :
1999PNAS...96.7992G .
doi :
10.1073/pnas.96.14.7992 .
PMC
22175 .
PMID
10393935 .
^
a
b
"Entrez Gene: DIDO1 death inducer-obliterator 1" .
Further reading
Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Nagase T, Ishikawa K, Nakajima D, et al. (1997).
"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 4 (2): 141–50.
doi :
10.1093/dnares/4.2.141 .
PMID
9205841 .
Deloukas P, Matthews LH, Ashurst J, et al. (2002).
"The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71.
Bibcode :
2001Natur.414..865D .
doi :
10.1038/414865a .
PMID
11780052 .
Gomes I, Sharma TT, Edassery S, et al. (2002).
"Novel transcription factors in human CD34 antigen-positive hematopoietic cells" . Blood . 100 (1): 107–19.
doi :
10.1182/blood.V100.1.107 .
PMID
12070015 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707–16.
doi :
10.1038/nbt971 .
PMID
15146197 .
S2CID
27764390 .
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics . 84 (1): 205–10.
doi :
10.1016/j.ygeno.2004.01.011 .
PMID
15203218 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Fütterer A, Campanero MR, Leonardo E, et al. (2005).
"Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms" . J. Clin. Invest . 115 (9): 2351–62.
doi :
10.1172/JCI24177 .
PMC
1190370 .
PMID
16127461 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92.
doi :
10.1038/nbt1240 .
PMID
16964243 .
S2CID
14294292 .
Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
Trachana V, van Wely KH, Guerrero AA, et al. (2007).
"Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability" . Proc. Natl. Acad. Sci. U.S.A . 104 (8): 2691–6.
Bibcode :
2007PNAS..104.2691T .
doi :
10.1073/pnas.0611132104 .
PMC
1815243 .
PMID
17299043 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors