Transcription factor HIVEP2 is a
protein that in humans is encoded by the HIVEP2gene.[5][6][7]
Function
Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2
zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific
DNA sequences, including the kappa-B motif (GGGACTTTCC), in the
promoters and
enhancer regions of several genes and
viruses, including human immunodeficiency virus (
HIV). ZAS genes span more than 150 kb and contain at least 10
exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sudo T, Ozawa K, Soeda EI, Nomura N, Ishii S (January 1992). "Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24". Genomics. 12 (1): 167–70.
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"Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28.
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PMID8889549.