From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Interferon regulatory factor 2 is a
protein that in humans is encoded by the IRF2
gene .
[5]
Function
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the
IRF1 -mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of
histone H4 .
[6]
See also
Interactions
IRF2 has been shown to
interact with
BRD7 ,
[7]
EP300
[8] and
PCAF .
[8]
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000168310 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031627 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell . 58 (4): 729–39.
doi :
10.1016/0092-8674(89)90107-4 .
PMID
2475256 .
S2CID
2033941 .
^
"Entrez Gene: IRF2 interferon regulatory factor 2" .
^ Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol . 185 (2): 269–79.
doi :
10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L .
PMID
11025449 .
S2CID
22932901 .
^
a
b Masumi A, Ozato K (June 2001).
"Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment" . J. Biol. Chem . 276 (24): 20973–80.
doi :
10.1074/jbc.M101707200 .
PMID
11304541 .
^ Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (March 1999).
"The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness" . Mol. Cell. Biol . 19 (3): 1810–20.
doi :
10.1128/MCB.19.3.1810 .
PMC
83974 .
PMID
10022868 .
Further reading
Harada H, Taniguchi T, Tanaka N (1999). "The role of interferon regulatory factors in the interferon system and cell growth control". Biochimie . 80 (8–9): 641–50.
doi :
10.1016/S0300-9084(99)80017-0 .
PMID
9865486 .
Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999).
"Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth" . Biochimie . 80 (8–9): 651–8.
doi :
10.1016/S0300-9084(99)80018-2 .
PMID
9865487 .
Itoh S, Harada H, Fujita T, Mimura T, Taniguchi T (1989).
"Sequence of a cDNA coding for human IRF-2" . Nucleic Acids Res . 17 (20): 8372.
doi :
10.1093/nar/17.20.8372 .
PMC
334978 .
PMID
2813069 .
Harada H, Takahashi E, Itoh S, Harada K, Hori TA, Taniguchi T (1994).
"Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system" . Mol. Cell. Biol . 14 (2): 1500–9.
doi :
10.1128/MCB.14.2.1500 .
PMC
358505 .
PMID
7507207 .
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995).
"Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3–174.
PMID
7566098 .
Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (1995).
"Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors" . J. Biol. Chem . 270 (22): 13063–9.
doi :
10.1074/jbc.270.22.13063 .
PMID
7768900 .
Cha Y, Deisseroth AB (1994).
"Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region" . J. Biol. Chem . 269 (7): 5279–87.
doi :
10.1016/S0021-9258(17)37685-8 .
PMID
8106512 .
Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara M, Taniguchi T (1993). "Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2". Science . 259 (5097): 971–4.
Bibcode :
1993Sci...259..971H .
doi :
10.1126/science.8438157 .
PMID
8438157 .
S2CID
41036818 .
Drew PD, Franzoso G, Carlson LM, Biddison WE, Siebenlist U, Ozato K (1996).
"Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells" . J. Neuroimmunol . 63 (2): 157–62.
doi :
10.1016/0165-5728(95)00140-9 .
PMID
8550813 .
S2CID
53166594 .
Birnbaum MJ, van Zundert B, Vaughan PS, Whitmarsh AJ, van Wijnen AJ, Davis RJ, Stein GS, Stein JL (1997). "Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo". J. Cell. Biochem . 66 (2): 175–83.
doi :
10.1002/(SICI)1097-4644(19970801)66:2<175::AID-JCB5>3.0.CO;2-N .
PMID
9213219 .
S2CID
34485265 .
Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (1999).
"The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness" . Mol. Cell. Biol . 19 (3): 1810–20.
doi :
10.1128/MCB.19.3.1810 .
PMC
83974 .
PMID
10022868 .
Li W, Nagineni CN, Hooks JJ, Chepelinsky AB, Egwuagu CE (1999). "Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors". Invest. Ophthalmol. Vis. Sci . 40 (5): 976–82.
PMID
10102295 .
Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, Trent JM, McFarland HF, Biddison WE (1999). "Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays". Ann. Neurol . 46 (3): 425–8.
doi :
10.1002/1531-8249(199909)46:3<425::AID-ANA22>3.0.CO;2-O .
PMID
10482277 .
S2CID
85574347 .
Mild GC, Schmahl GE, Shayan P, Niemeyer CM (2000). "Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia". Leuk. Lymphoma . 35 (5–6): 507–11.
doi :
10.1080/10428199909169615 .
PMID
10609788 .
Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol . 185 (2): 269–79.
doi :
10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L .
PMID
11025449 .
S2CID
22932901 .
Larrea E, Alberdi A, Castelruiz Y, Boya P, Civeira MP, Prieto J (2001). "Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5". J. Viral Hepat . 8 (2): 103–10.
doi :
10.1046/j.1365-2893.2001.00273.x .
PMID
11264730 .
S2CID
55595193 .
Masumi A, Ozato K (2001).
"Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment" . J. Biol. Chem . 276 (24): 20973–80.
doi :
10.1074/jbc.M101707200 .
PMID
11304541 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
PDB gallery
1irf : INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
1irg : INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES
2irf : CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors