From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
CAMP responsive element binding protein-like 1, also known as CREBL1, is a
protein which in humans is encoded by the CREBL1
gene.
[5]
[6]
Function
The protein encoded by this gene bears sequence similarity with the
Creb/ATF subfamily of the
bZip superfamily of
transcription factors. It localizes to both the
cytoplasm and the
nucleus. The gene localizes to the
major histocompatibility complex (MHC) class III region on
chromosome 6.
[5]
References
- ^
a
b
c
ENSG00000228628, ENSG00000234539, ENSG00000168468 GRCh38: Ensembl release 89: ENSG00000213676, ENSG00000228628, ENSG00000234539, ENSG00000168468 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000015461 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^
a
b
"Entrez Gene: CREBL1 cAMP responsive element binding protein-like 1".
-
^ Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K (April 2001).
"Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response". Biochem. J. 355 (Pt 1): 19–28.
doi:
10.1042/0264-6021:3550019.
PMC
1221707.
PMID
11256944.
Further reading
- Bristow J, Tee MK, Gitelman SE, et al. (1993).
"Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B". J. Cell Biol. 122 (1): 265–78.
doi:
10.1083/jcb.122.1.265.
PMC
2119596.
PMID
7686164.
- Min J, Shukla H, Kozono H, et al. (1996).
"A novel Creb family gene telomeric of HLA-DRA in the HLA complex". Genomics. 30 (2): 149–56.
doi:
10.1006/geno.1995.9891.
PMID
8586413.
- Khanna A, Campbell RD (1996).
"The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein". Biochem. J. 319. ( Pt 1) (Pt 1): 81–9.
doi:
10.1042/bj3190081.
PMC
1217738.
PMID
8870652.
- Speek M, Barry F, Miller WL (1997).
"Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes". Hum. Mol. Genet. 5 (11): 1749–58.
doi:
10.1093/hmg/5.11.1749.
PMID
8923003.
- Swanson DJ, Adachi M, Lewis EJ (2000).
"The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein". J. Biol. Chem. 275 (4): 2911–23.
doi:
10.1074/jbc.275.4.2911.
PMID
10644760.
- Yoshida H, Okada T, Haze K, et al. (2001).
"Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response". Mol. Cell. Biol. 21 (4): 1239–48.
doi:
10.1128/MCB.21.4.1239-1248.2001.
PMC
99577.
PMID
11158310.
- Ye J, Rawson RB, Komuro R, et al. (2001).
"ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs". Mol. Cell. 6 (6): 1355–64.
doi:
10.1016/S1097-2765(00)00133-7.
PMID
11163209.
- Haze K, Okada T, Yoshida H, et al. (2001).
"Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response". Biochem. J. 355 (Pt 1): 19–28.
doi:
10.1042/0264-6021:3550019.
PMC
1221707.
PMID
11256944.
- Tong WY, Nagano-Fujii M, Hidajat R, et al. (2003).
"Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta" (PDF). Biochem. Biophys. Res. Commun. 299 (3): 366–72.
doi:
10.1016/S0006-291X(02)02638-4.
PMID
12445808. Archived from
the original (PDF) on 2020-07-12. Retrieved 2020-09-05.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Okada T, Haze K, Nadanaka S, et al. (2003).
"A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6". J. Biol. Chem. 278 (33): 31024–32.
doi:
10.1074/jbc.M300923200.
PMID
12782636.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003).
"The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11.
Bibcode:
2003Natur.425..805M.
doi:
10.1038/nature02055.
PMID
14574404.
- Xie T, Rowen L, Aguado B, et al. (2004).
"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36.
doi:
10.1101/gr.1736803.
PMC
403804.
PMID
14656967.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.
doi:
10.1038/ng1285.
PMID
14702039.
External links
This article incorporates text from the
United States National Library of Medicine, which is in the
public domain.
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(1) Basic domains |
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(1.1) Basic
leucine zipper (
bZIP) | |
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(1.2) Basic helix-loop-helix (
bHLH) | Group A | |
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Group B | |
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Group C bHLH-
PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3)
bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2)
Zinc finger DNA-binding domains |
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(2.1)
Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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