Nuclear factor of activated T-cells, cytoplasmic 4 is a
protein that in humans is encoded by the NFATC4gene.[5][6]
Function
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon
T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of
cytokine genes in T cells, especially in the induction of the
IL-2 and
IL-4.[6]
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