From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Interferon regulatory factor 7 , also known as IRF7 , is a member of the
interferon regulatory factor family of
transcription factors .
Function
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of
virus-inducible cellular genes , including the
type I interferon genes. In particular, IRF7 regulates many
interferon-alpha genes.
[5] Constitutive expression of IRF7 is largely restricted to
lymphoid tissue , largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
[6]
The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response.
[7] Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.
The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1
influenza , while susceptibility to other viral diseases such as CMV, RSV, and
parainfluenza was unaffected.
[8]
Interactions
IRF7 has been shown to
interact with
IRF3 .
[9] Also, IRF7 has been shown to interact with
Aryl Hydrocarbon Receptor Interacting Protein (AIP) , which is a negative regulator for the antiviral pathway.
[10]
See also
References
^
a
b
c
ENSG00000185507 GRCh38: Ensembl release 89: ENSG00000276561, ENSG00000185507 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000025498 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Marié I, Durbin JE, Levy DE (November 1998).
"Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7" . The EMBO Journal . 17 (22): 6660–9.
doi :
10.1093/emboj/17.22.6660 .
PMC
1171011 .
PMID
9822609 .
^
"Entrez Gene: IRF7 interferon regulatory factor 7" .
^ Bidwell (2012). "Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape". Nature Medicine . 18 (8): 1224–1231.
doi :
10.1038/nm.2830 .
PMID
22820642 .
S2CID
6727932 .
^ Ciancanelli MJ, Huang SX, Luthra P, Garner H, Itan Y, Volpi S, Lafaille FG, Trouillet C, Schmolke M, Albrecht RA, Israelsson E, Lim HK, Casadio M, Hermesh T, Lorenzo L, Leung LW, Pedergnana V, Boisson B, Okada S, Picard C, Ringuier B, Troussier F, Chaussabel D, Abel L, Pellier I, Notarangelo LD, García-Sastre A, Basler CF, Geissmann F, Zhang SY, Snoeck HW, Casanova JL (April 2015).
"Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency" . Science . 348 (6233): 448–53.
doi :
10.1126/science.aaa1578 .
PMC
4431581 .
PMID
25814066 .
^ Au WC, Yeow WS, Pitha PM (February 2001).
"Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3" . Virology . 280 (2): 273–82.
doi :
10.1006/viro.2000.0782 .
PMID
11162841 .
^ Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW (June 2015).
"Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon" . The Journal of Biological Chemistry . 290 (23): 14729–39.
doi :
10.1074/jbc.M114.633065 .
PMC
4505538 .
PMID
25911105 .
Further reading
Ning S, Pagano JS, Barber GN (September 2011).
"IRF7: activation, regulation, modification and function" . Genes and Immunity . 12 (6): 399–414.
doi :
10.1038/gene.2011.21 .
PMC
4437765 .
PMID
21490621 .
Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999).
"Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth" . Biochimie . 80 (8–9): 651–8.
doi :
10.1016/S0300-9084(99)80018-2 .
PMID
9865487 .
Zhang L, Pagano JS (January 2002). "Structure and function of IRF-7". Journal of Interferon & Cytokine Research . 22 (1): 95–101.
doi :
10.1089/107999002753452700 .
PMID
11846980 .
Zhang L, Pagano JS (October 1997).
"IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency" . Molecular and Cellular Biology . 17 (10): 5748–57.
doi :
10.1128/MCB.17.10.5748 .
PMC
232423 .
PMID
9315633 .
Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T (March 1998).
"Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo" . Molecular Cell . 1 (4): 507–18.
doi :
10.1016/S1097-2765(00)80051-9 .
PMID
9660935 .
Au WC, Moore PA, LaFleur DW, Tombal B, Pitha PM (October 1998).
"Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes" . The Journal of Biological Chemistry . 273 (44): 29210–7.
doi :
10.1074/jbc.273.44.29210 .
PMID
9786932 .
Lu R, Au WC, Yeow WS, Hageman N, Pitha PM (October 2000).
"Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon and silencing by hypermethylation" . The Journal of Biological Chemistry . 275 (41): 31805–12.
doi :
10.1074/jbc.M005288200 .
PMID
10924517 .
Paris MJ, Williams BR (October 2000). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics . 69 (2): 196–202.
doi :
10.1006/geno.2000.6339 .
PMID
11031102 .
Marié I, Smith E, Prakash A, Levy DE (December 2000).
"Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain" . Molecular and Cellular Biology . 20 (23): 8803–14.
doi :
10.1128/MCB.20.23.8803-8814.2000 .
PMC
86519 .
PMID
11073981 .
Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE (March 2001).
"IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein" . The Journal of Biological Chemistry . 276 (12): 8951–7.
doi :
10.1074/jbc.M008717200 .
PMID
11124948 .
Au WC, Yeow WS, Pitha PM (February 2001).
"Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3" . Virology . 280 (2): 273–82.
doi :
10.1006/viro.2000.0782 .
PMID
11162841 .
Lu R, Moore PA, Pitha PM (May 2002).
"Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility" . The Journal of Biological Chemistry . 277 (19): 16592–8.
doi :
10.1074/jbc.M111440200 .
PMID
11877397 .
Morin P, Bragança J, Bandu MT, Lin R, Hiscott J, Doly J, Civas A (March 2002). "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription". Journal of Molecular Biology . 316 (5): 1009–22.
doi :
10.1006/jmbi.2001.5401 .
PMID
11884139 .
Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I (December 2002).
"Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding" . The Journal of Biological Chemistry . 277 (51): 49417–21.
doi :
10.1074/jbc.M207484200 .
PMID
12374802 .
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine . 9 (2): 191–7.
doi :
10.1038/nm822 .
PMID
12539042 .
S2CID
26145639 .
Yang H, Lin CH, Ma G, Baffi MO, Wathelet MG (May 2003).
"Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators" . The Journal of Biological Chemistry . 278 (18): 15495–504.
doi :
10.1074/jbc.M212940200 .
PMID
12604599 .
Ning S, Hahn AM, Huye LE, Pagano JS (September 2003).
"Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit" . Journal of Virology . 77 (17): 9359–68.
doi :
10.1128/JVI.77.17.9359-9368.2003 .
PMC
187426 .
PMID
12915551 .
Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT (October 2003).
"LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF" . The Journal of Experimental Medicine . 198 (7): 1043–55.
doi :
10.1084/jem.20031023 .
PMC
2194210 .
PMID
14517278 .
Lin R, Noyce RS, Collins SE, Everett RD, Mossman KL (February 2004).
"The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes" . Journal of Virology . 78 (4): 1675–84.
doi :
10.1128/JVI.78.4.1675-1684.2004 .
PMC
369457 .
PMID
14747533 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors