From Wikipedia, the free encyclopedia
Receptors on the surface of cells
Type I
cytokine receptors are
transmembrane receptors expressed on the surface of cells that recognize and respond to
cytokines with four
α-helical strands. These receptors are also known under the name
hemopoietin receptors , and share a common
amino acid motif (
WSXWS ) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in
ligand /cytokine interaction and others that are involved in
signal transduction .
The common cytokine-binding domain is related to the
Fibronectin type III domain .
Signal transduction chains
The signal transducing chains are often shared between different receptors within this receptor family.
[1]
The IL-2 receptor
common gamma chain (also known as CD132) is shared between:
The common beta chain (
CD131 or CDw131) is shared between the following type I cytokine receptors:
The gp130 receptor (
Glycoprotein 130 ) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
Examples
Type I cytokine receptors include
interleukin receptors,
colony stimulating factor receptors and other cytokine receptors
Interleukin receptors
Colony stimulating factor receptors
Hormone receptor/neuropeptide receptor
Other
References
^ Lichtman, Andrew H.; Abbas, Abul K. (2003). Cellular and molecular immunology (5th ed.). Philadelphia: Saunders.
ISBN
0-7216-0008-5 .
^ He YW, Adkins B, Furse RK, Malek TR (1995).
"Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor" . J. Immunol . 154 (4): 1596–605.
PMID
7530740 .
^ Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster K, Sugamura K (2001).
"Cutting edge: the common γ-chain is an indispensable subunit of the IL21 receptor complex" . J. Immunol . 167 (1): 1–5.
doi :
10.4049/jimmunol.167.1.1 .
PMID
11418623 .
^ Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF (1998).
"Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors" . J. Biol. Chem . 273 (2): 1192–9.
doi :
10.1074/jbc.273.2.1192 .
PMID
9422786 .
^ Cirillo, Donatella; Rachiglio, Anna Maria; la Montagna, Raffaele; Giordano, Antonio; Normanno, Nicola (1 November 2008). "Leptin signaling in breast cancer: An overview". Journal of Cellular Biochemistry . 105 (4): 956–964.
doi :
10.1002/jcb.21911 .
PMID
18821585 .
External links
Chemokine
CSF
Interferon
IFNAR (α/β, I)
Agonists:
Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (
IFNA1 ,
IFNA2 ,
IFNA4 ,
IFNA5 ,
IFNA6 ,
IFNA7 ,
IFNA8 ,
IFNA10 ,
IFNA13 ,
IFNA14 ,
IFNA16 ,
IFNA17 ,
IFNA21 )
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (
IFNB1 ,
IFNB3 )
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
IFNGR (γ, II)
IFNLR (λ, III)
See IL-28R (IFNLR)
here instead.
Interleukin
TGFβ
TNF Others