From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Zinc finger protein ubi-d4 is a
protein that in humans is encoded by the DPF2
gene .
[5]
[6]
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a
transcription factor which is necessary for the
apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid
hematopoietic cell growth and turnover. This gene is considered a candidate gene for
multiple endocrine neoplasia type I , an inherited
cancer syndrome involving multiple
parathyroid , enteropancreatic, and
pituitary tumors.
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000133884 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000024826 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome . 12 (11): 862–6.
doi :
10.1007/s00335-001-3039-1 .
PMID
11845289 .
S2CID
2149578 .
^
a
b
"Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2" .
Further reading
Gabig TG, Mantel PL, Rosli R, Crean CD (1994).
"Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells" . J. Biol. Chem . 269 (47): 29515–9.
doi :
10.1016/S0021-9258(18)43910-5 .
PMID
7961935 .
Chestkov AV, Baka ID, Kost MV, et al. (1997). "The d4 gene family in the human genome". Genomics . 36 (1): 174–7.
doi :
10.1006/geno.1996.0440 .
PMID
8812431 .
Guru SC, Agarwal SK, Manickam P, et al. (1997).
"A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus" . Genome Res . 7 (7): 725–35.
doi :
10.1101/gr.7.7.725 .
PMC
310681 .
PMID
9253601 .
Gabig TG, Crean CD, Klenk A, et al. (1998). "Expression and chromosomal localization of the Requiem gene". Mamm. Genome . 9 (8): 660–5.
doi :
10.1007/s003359900840 .
PMID
9680388 .
S2CID
22559464 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol . 6 (2): 97–105.
doi :
10.1038/ncb1086 .
PMID
14743216 .
S2CID
11683986 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors