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Chemical compound
Etanautine
ATC code
2-[di(phenyl)methoxy]-N,N-dimethylethanamine; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid
CAS Number
ChemSpider
UNII
Formula C 26 H 31 N 5 O 5
Molar mass 493.564 g·mol−1 3D model (
JSmol )
O=C2N(c1ncn(c1C(=O)N2C)CC(=O)O)C.O(CCN(C)C)C(c1ccccc1)c2ccccc2
InChI=1S/C17H21NO.C9H10N4O4/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h3-12,17H,13-14H2,1-2H3;4H,3H2,1-2H3,(H,14,15)
Key:UFKLOBYBVCBTBP-UHFFFAOYSA-N
(verify)
Etanautine , also known as diphenhydramine monoacefyllinate , is an
anticholinergic used as an
antiparkinsonian agent. It is a 1:1 salt of
diphenhydramine with
acefylline , similar to the diphenhydramine/8-chlorotheophylline combination product
dimenhydrinate .
[1]
As with dimenhydrinate, the stimulant effect of the etanautine counteracts the sedative effect from the diphenhydramine, resulting in an improved therapeutic profile.
[2]
The 1:2 salt diphenhydramine diacefylline (with two molecules of acefylline to each molecule of diphenhydramine) is also used in medicine, under the brand name Nautamine .
[1]
[3]
References
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