Compared to the unsubstituted
ethylamphetamine, 3-fluoroethamphetamine is a weaker releaser of noradrenaline, but a stronger releaser of both dopamine and serotonin, and produced the strongest reinforcing effects in animal studies out of a range of 3-substituted ethamphetamine derivatives tested, despite not being the most potent dopamine releaser.[1][2][3][4]
^Tessel RE, Woods JH (1974). "Structural relationship between meta-substituted N-ethylamphetamines and self-administration in rhesus monkeys". Pharmacologist. 16: 142.
^Tessel RE, Woods JH, Counsell RE, Lu M (February 1975). "Structure-activity relationships between meta-substituted N-ethylamphetamines and locomotor activity in mice". The Journal of Pharmacology and Experimental Therapeutics. 192 (2): 310–8.
PMID1117418.
^Tessel RE, Rutledge CO (May 1976). "Specificity of release of biogenic amines from isolated rat brain tissue as a function of the meta substituent of N-ethylamphetamine derivatives". The Journal of Pharmacology and Experimental Therapeutics. 197 (2): 253–62.
PMID1271279.
^Tessel RE, Woods JH (May 1978). "meta Substituted N-ethylamphetamine self injection responding in the rhesus monkey: structure-activity relationships". The Journal of Pharmacology and Experimental Therapeutics. 205 (2): 274–81.
PMID417172.