Dimethylamphetamine (Metrotonin), also known as dimetamfetamine (
INN), dimephenopan and N,N-dimethylamphetamine, is a
stimulantdrug of the
phenethylamine and
amphetaminechemical classes. Dimethylamphetamine has weaker stimulant effects than
amphetamine or
methamphetamine and is considerably less addictive[1] and less neurotoxic compared to methamphetamine.[2][3] However, it still retains some mild stimulant effects and abuse potential,[4] and is a
Schedule I controlled drug.
Dimethylamphetamine has occasionally been found in illicit methamphetamine laboratories, but is usually an impurity rather than the desired product. It may be produced by accident when methamphetamine is synthesised by
methylation of amphetamine if the reaction temperature is too high or an excess of methylating agent is used.[5][6]
^Witkin JM, Ricaurte GA, Katz JL (May 1990). "Behavioral effects of N-methylamphetamine and N,N-dimethylamphetamine in rats and squirrel monkeys". The Journal of Pharmacology and Experimental Therapeutics. 253 (2): 466–74.
PMID2338643.
^Ricaurte GA, DeLanney LE, Irwin I, Witkin JM, Katz JL, Langston JW (June 1989). "Evaluation of the neurotoxic potential of N,N-dimethylamphetamine: an illicit analog of methamphetamine". Brain Research. 490 (2): 301–6.
doi:
10.1016/0006-8993(89)90247-3.
PMID2765865.
S2CID20682993.