From Wikipedia, the free encyclopedia
ZM-241,385
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Names
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Preferred IUPAC name
4-(2-{[7-Amino-2-(furan-2-yl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino}ethyl)phenol
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Identifiers
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ChEMBL
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ChemSpider
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ECHA InfoCard
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100.216.533
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UNII
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InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22) NKey: PWTBZOIUWZOPFT-UHFFFAOYSA-N NInChI=1/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22) Key: PWTBZOIUWZOPFT-UHFFFAOYAJ
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Oc1ccc(CCNc2nc3nc(c4ccco4)nn3c(N)n2)cc1
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Properties
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C16H15N7O2
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Molar mass
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337.343 g·mol−1
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
ZM-241,385 is a high affinity
antagonist
ligand selective for the
adenosine A2A receptor.
[1]
In animal models, ZM-241,385 has been shown to protect against
beta amyloid
neurotoxicity and therefore may be useful as a treatment for
Alzheimer's disease.
[2] ZM-241,385 has also been shown to enhance
L-DOPA derived
dopamine release and therefore may be useful in the treatment of
Parkinson's disease.
[3]
References
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^ Palmer TM, Poucher SM, Jacobson KA, Stiles GL (December 1995).
"125I-4-(2-(7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5) triazin-5-yl-amino)ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor". Molecular Pharmacology. 48 (6): 970–4.
PMC
3479638.
PMID
8848012.
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^ Dall'Igna OP, Porciúncula LO, Souza DO, Cunha RA, Lara DR, Dall'lgna OP (April 2003).
"Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity".
British Journal of Pharmacology. 138 (7): 1207–9.
doi:
10.1038/sj.bjp.0705185.
PMC
1573785.
PMID
12711619.
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^ Gołembiowska K, Dziubina A (September 2004). "Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats". Neuropharmacology. 47 (3): 414–26.
doi:
10.1016/j.neuropharm.2004.04.018.
PMID
15275831.
S2CID
13484028.
External links
ZM+241385 at the U.S. National Library of Medicine
Medical Subject Headings (MeSH)