3β-(4-Methylphenyl)-2β-[3-(4-chlorophenyl)isoxazol-5-yl]tropane (RTI-4229-371) is a
phenyltropane derived drug which acts as a potent and selective
dopamine reuptake inhibitorin vitro, yet unusually for this class of compound, both RTI-371 and the closely related compound
RTI-370 failed to produce
locomotor stimulation in mice. In addition to this, in drug substitution tests RTI-370 weakly generalized to cocaine whereas RTI-371 did not generalize at all.
This phenomenon has also been observed for other dopamine reuptake inhibitors from other classes. It may be caused by lack of
BBB penetration, or interactions at alternative receptor sites.[1][2]