From Wikipedia, the free encyclopedia
Benzhydryl compound
Tolterodine , sold under the brand name Detrol among others, is a
medication used to treat
frequent urination ,
urinary incontinence , or
urinary urgency .
[5] Effects are seen within an hour.
[6] It is taken by mouth.
[6]
[7]
Common side effects include headache, dry mouth, constipation, and dizziness.
[6] Serious side effects may include
angioedema ,
urinary retention , and
QT prolongation .
[6] Use in
pregnancy and
breastfeeding are of unclear safety.
[5]
[8] It works by
blocking muscarinic receptors in the
bladder thus decreasing bladder contractions.
[6]
Tolterodine was approved for medical use in 1998.
[6] It is available as a
generic medication .
[5] In 2020, it was the 271st most commonly prescribed medication in the United States, with more than 1 million prescriptions.
[9]
[10]
Medical uses
Detrusor overactivity (DO, contraction of the muscular bladder wall) is the most common form of urinary incontinence (UI) in older adults.[
medical citation needed ] It is characterized by uninhibited bladder contractions causing an uncontrollable urge to void.[
medical citation needed ] Urinary frequency, urge incontinence and nocturnal incontinence occur.[
medical citation needed ] Abnormal bladder contractions that coincide with the urge to void can be measured by
urodynamic studies .[
medical citation needed ] Treatment is bladder retraining,
[11] [
unreliable medical source? ]
pelvic floor therapy or with drugs that inhibit bladder contractions such as
oxybutynin and tolterodine.[
medical citation needed ]
Side effects
Known side effects:
The following reactions have been reported in people who have taken tolterodine since it has become available:
Tolterodine is not recommended for use in people with
myasthenia gravis and
angle closure glaucoma .
Pharmacology
Tolterodine acts on M2 and M3
[12] subtypes of
muscarinic receptors whereas older
antimuscarinic treatments for overactive bladder act more specifically on M3 receptors.[
medical citation needed ]
Tolterodine, although it acts on all types of receptors, has fewer side effects than
oxybutynin (M3 and M1 selective, but more so in the parotid than in the bladder) as tolterodine targets the bladder more than other areas of the body.[
medical citation needed ]
Society and culture
Brand names
It is marketed by
Pfizer in Canada and the United States under the brand name Detrol. In Egypt it is also found under the trade names Tolterodine by Sabaa and Incont L.A. by Adwia.
References
External links
"Tolterodine" . Drug Information Portal . U.S. National Library of Medicine.
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