From Wikipedia, the free encyclopedia
Chemical compound
Dimetindene , also sold under the brand name Fenistil , is an
antihistamine /
anticholinergic . It is a first generation
[1] selective
H1 antagonist .
[2] Dimetindene is an atypical first generation H1 antagonist as it only minimally
[3] passes across the
blood–brain barrier .
Dimetindene is also an
M2 receptor antagonist.
[4]
It was patented in 1958 and came into medical use in 1960.
[5]
Medical use
Dimetindene is used orally and topically as an
antipruritic .
[6] It is used topically to treat skin irritations, such as insect bites. Dimetindene is also administered orally to treat allergies, such as
hay fever .
It is commonly
formulated as its
maleic acid
salt , dimethindene maleate.
Names
It is sold under the brand name
Fenistil among others.
References
^ Fromer LM, Ortiz GR, Dowdee AM (September 2008).
"Assessment of Patient Attitudes About Mometasone Furoate Nasal Spray: The Ease-of-Use Patient Survey" . The World Allergy Organization Journal . 1 (9): 156–159.
doi :
10.1186/1939-4551-1-9-145 .
PMC
3651039 .
PMID
23282579 .
^
"Dimetindene" . Drugs.com .
^ Noguchi S, Inukai T, Kuno T, Tanaka C (June 1992). "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior . 51 (6): 1123–1127.
doi :
10.1016/0031-9384(92)90297-f .
PMID
1353628 .
S2CID
29562845 .
^ Matsumoto Y, Miyazato M, Furuta A, Torimoto K, Hirao Y, Chancellor MB, Yoshimura N (April 2010).
"Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats" . Urology . 75 (4): 862–867.
doi :
10.1016/j.urology.2009.12.013 .
PMC
2871158 .
PMID
20156651 .
^ Fischer J, Ganellin CR (2006).
Analogue-based Drug Discovery . John Wiley & Sons. p. 547.
ISBN
9783527607495 .
^ Wexler L (June 1962). "A clinical evaluation of dimethindene". Current Therapeutic Research, Clinical and Experimental . 4 : 306–309.
PMID
14006402 .
H1
Agonists Antagonists
Others:
Atypical antipsychotics (e.g.,
aripiprazole ,
asenapine ,
brexpiprazole ,
brilaroxazine ,
clozapine ,
iloperidone ,
olanzapine ,
paliperidone ,
quetiapine ,
risperidone ,
ziprasidone ,
zotepine )
Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone ,
nefazodone ,
trazodone ,
triazoledione )
Tetracyclic antidepressants (e.g.,
amoxapine ,
loxapine ,
maprotiline ,
mianserin ,
mirtazapine ,
oxaprotiline )
Tricyclic antidepressants (e.g.,
amitriptyline ,
butriptyline ,
clomipramine ,
desipramine ,
dosulepin (dothiepin) ,
doxepin ,
imipramine ,
iprindole ,
lofepramine ,
nortriptyline ,
protriptyline ,
trimipramine )
Typical antipsychotics (e.g.,
chlorpromazine ,
flupenthixol ,
fluphenazine ,
loxapine ,
perphenazine ,
prochlorperazine ,
thioridazine ,
thiothixene )
H2
H3
H4
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AQ-RA 741
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PD-102,807
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+vilanterol )
WIN-2299
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Precursors (and
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