Chemically, clobenzorex is an N-substituted amphetamine
prodrug that is metabolized primarily into 4-hydroxyclobenzorex after ingestion; however, small amounts are also metabolized into
dextroamphetamine.[4] In commercial production, clobenzorex is supplied as the
hydrochloride salt in green-tinted capsules. The drug gained use as a prescription
anorectic in the 1970s.
Apparently, also made from the acid chloride, and reduction of the amide with lithium aluminium anhydride.[citation needed]
Detection in urine
Clobenzorex can be
detected in urine, which can cause false positives for workplace drug screening.[8] It is one of many drugs that can cause false positives for amphetamine urine drug screening.[9] It may be differentiated from amphetamine use through testing for metabolites such as 4-hydroxyclobenzorex[10] or
enantiomeric analysis.[8]
Society and culture
Legal status
In Canada, Clobenzorex is not specifically listed in the CDSA, however due to structural similarities with norbenzphetamine, it is a schedule I under item 19(17).[citation needed]
The substance is not scheduled in the United States and is unaffected by the
Federal Analogue Act as a derivative of
Benzphetamine. Clobenzorex is legal in the United States of America. [13]
Clobenzorex is not controlled within the United States or subject to import controls. Importation of clobenzorex for personal use is lawful provided that is for use to treat a condition with no
approved medications, unlawful marketing is not occurring in the U.S, not deemed hazardous to health for the treating the condition, and is verified as a continuation of a treatment plan that began in a foreign country.[14]
^Young R, Darmani NA, Elder EL, Dumas D, Glennon RA (February 1997). "Clobenzorex: evidence for amphetamine-like behavioral actions". Pharmacology, Biochemistry, and Behavior. 56 (2): 311–316.
doi:
10.1016/s0091-3057(96)00329-2.
PMID9050090.
S2CID37062225.
^Cody JT (2005).
"Amphetamines: methods of forensic analysis.". In Smith F, Athanaselis SS (eds.). Handbook of Forensic Drug Analysis. Elsevier. pp. 357–451 (430).
ISBN978-0-08-047289-8. Amphetamine produced from the metabolism of clobenzorex has been shown to be the d-enantiomer only ...
^Boissier JR, Ratouis R, Dumont C (January 1966). "[New derivatives of phenylisopropylamine: synthesis and study of their anorexic activity]". Annales Pharmaceutiques Françaises (in French). 24 (1): 57–68.
PMID5910702.
^GB 1123565, "New substituted benzylamines and their salts and process for preparation", issued 1968, assigned to Soc. Ind. Fabric. Antibiot.
^Lintermans J, Benakis A, Ratouis R (July 1970). "Synthèse du chlorhydrate de (+)-N-(o-chlorobenzyl) α-methyl phénéthylamine marqué en position 7 par 14C (chlorhydrate de clobenzorex)". Journal of Labelled Compounds. 6 (3): 289–297.
doi:
10.1002/jlcr.2590060310.