RTI(-4229)-150, ((−)-2β-Carbocyclobutoxy-3β-(4-methylphenyl)tropane) is a
phenyltropane derivative which acts as a potent
dopamine reuptake inhibitor and
stimulant drug. It is around 5x more potent than
cocaine, but is more selective for the
dopamine transporter relative to the other monoamine transporters. RTI-150 has a fast onset of effects and short duration of action, and its
abuse potential in animal studies is similar to that of cocaine itself; its main application in scientific research has been in studies investigating the influence of
pharmacokinetics on the abuse potential of stimulant drugs, with the rapid entry of RTI-150 into the brain thought to be a key factor in producing its high propensity for development of dependence in animals.[1][2][3] RTI-150 is not explicitly illegal anywhere in the world, but its similar structure and pharmacological activity to cocaine makes it possible that it would be considered a
controlled substance analogue in countries such as the US, Canada, Australia and New Zealand which have controlled substance analogue legislation.