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Chemical compound
"NRG-5" redirects here. For the compact food biscuit used for disaster relief, see
BP-5 Compact Food .
5-Iodo-2-aminoindane (5-IAI ) is a
drug which acts as a
releasing agent of
serotonin ,
norepinephrine , and
dopamine .
[2] It was developed in the 1990s by a team led by
David E. Nichols at
Purdue University .
[3] 5-IAI fully substitutes for
MDMA in rodents and is a putative
entactogen in humans.
[3] Unlike related
aminoindane derivatives like
MDAI and
MMAI , 5-IAI causes some
serotonergic
neurotoxicity in rats, but is substantially less toxic than its corresponding
amphetamine homologue
pIA , with the damage observed barely reaching statistical significance.
[2]
Legal status
Sweden's public health agency suggested classifying 5-IAI as a hazardous substance, on September 25, 2019.
[4]
References
^
Anvisa (2023-07-24).
"RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).
Diário Oficial da União (published 2023-07-25).
Archived from the original on 2023-08-27. Retrieved 2023-08-27 .
^
a
b Johnson MP, Conarty PF, Nichols DE (July 1991). "[3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". European Journal of Pharmacology . 200 (1): 9–16.
doi :
10.1016/0014-2999(91)90659-E .
PMID
1685125 .
^
a
b Nichols DE, Johnson MP, Oberlender R (January 1991). "5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine". Pharmacology Biochemistry and Behavior . 38 (1): 135–9.
doi :
10.1016/0091-3057(91)90601-W .
PMID
1826785 .
S2CID
20485505 .
^
"Tretton ämnen föreslås klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 25 September 2019. Archived from
the original on 31 October 2019. Retrieved 11 November 2019 .
DRAs Tooltip Dopamine releasing agents
NRAs Tooltip Norepinephrine releasing agents
SRAs Tooltip Serotonin releasing agents
Others