From Wikipedia, the free encyclopedia
Chemical compound
PNU-120596 is a drug that acts as a potent and selective
positive allosteric modulator for the
α7 subtype of neural
nicotinic acetylcholine receptors .
[1]
[2] It is used in scientific research into cholinergic regulation of dopamine and glutamate release in the brain.
[3]
[4]
[5]
References
^ Hurst RS, Hajós M, Raggenbass M, Wall TM, Higdon NR, Lawson JA, et al. (April 2005).
"A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization" . The Journal of Neuroscience . 25 (17): 4396–405.
doi :
10.1523/JNEUROSCI.5269-04.2005 .
PMC
6725110 .
PMID
15858066 .
^ Young GT, Zwart R, Walker AS, Sher E, Millar NS (September 2008).
"Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site" . Proceedings of the National Academy of Sciences of the United States of America . 105 (38): 14686–91.
Bibcode :
2008PNAS..10514686Y .
doi :
10.1073/pnas.0804372105 .
PMC
2535569 .
PMID
18791069 .
^ Livingstone PD, Srinivasan J, Kew JN, Dawson LA, Gotti C, Moretti M, et al. (February 2009).
"alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex" . The European Journal of Neuroscience . 29 (3): 539–50.
doi :
10.1111/j.1460-9568.2009.06613.x .
PMID
19187266 .
S2CID
13289370 .
^ Barron SC, McLaughlin JT, See JA, Richards VL, Rosenberg RL (August 2009).
"An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine" . Molecular Pharmacology . 76 (2): 253–63.
doi :
10.1124/mol.109.056226 .
PMC
2713121 .
PMID
19411608 .
^ Livingstone PD, Dickinson JA, Srinivasan J, Kew JN, Wonnacott S (January 2010). "Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596". Journal of Molecular Neuroscience . 40 (1–2): 172–6.
doi :
10.1007/s12031-009-9232-5 .
PMID
19688191 .
S2CID
29929913 .
nAChRs Tooltip Nicotinic acetylcholine receptors
Agonists (and
PAMs Tooltip positive allosteric modulators )
5-HIAA
6-Chloronicotine
A-84,543
A-366,833
A-582,941
A-867,744
ABT-202
ABT-418
ABT-560
ABT-894
Acetylcholine
Altinicline
Anabasine
Anatabine
Anatoxin-a
AR-R17779
Bephenium hydroxynaphthoate
Butinoline
Butyrylcholine
Carbachol
Choline
Cotinine
Cytisine
Decamethonium
Desformylflustrabromine
Dianicline
Dimethylphenylpiperazinium
Epibatidine
Epiboxidine
Ethanol (alcohol)
Ethoxysebacylcholine
EVP-4473
EVP-6124
Galantamine
GTS-21
Ispronicline
Ivermectin
JNJ-39393406
Levamisole
Lobeline
MEM-63,908 (RG-3487)
Morantel
Nicotine (
tobacco )
NS-1738
PHA-543,613
PHA-709,829
PNU-120,596
PNU-282,987
Pozanicline
Pyrantel
Rivanicline
RJR-2429
Sazetidine A
SB-206553
Sebacylcholine
SIB-1508Y
SIB-1553A
SSR-180,711
Suberyldicholine
Suxamethonium (succinylcholine)
Suxethonium (succinyldicholine)
TC-1698
TC-1734
TC-1827
TC-2216
TC-5214
TC-5619
TC-6683
Tebanicline
Tribendimidine
Tropisetron
UB-165
Varenicline
WAY-317,538
XY-4083
Antagonists (and
NAMs Tooltip negative allosteric modulators )
Precursors (and
prodrugs )