From Wikipedia, the free encyclopedia
Chemical compound
For the process algebra, see
PEPA.
PEPA is a
sulfonamide
AMPA receptor
positive allosteric modulator,
[1]
[2] which is up to 100 times more potent than
aniracetam in vitro.
[3] It produces memory-enhancing effects in rats when administered intravenously.
[4]
See also
References
-
^ Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, et al. (April 1998).
"Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures". British Journal of Pharmacology. 123 (7): 1294–303.
doi:
10.1038/sj.bjp.0701707.
PMC
1565288.
PMID
9579722.
-
^ Sekiguchi M, Nishikawa K, Aoki S, Wada K (August 2002).
"A desensitization-selective potentiator of AMPA-type glutamate receptors". British Journal of Pharmacology. 136 (7): 1033–41.
doi:
10.1038/sj.bjp.0704804.
PMC
1573432.
PMID
12145103.
-
^ Sekiguchi M, Fleck MW, Mayer ML, Takeo J, Chiba Y, Yamashita S, Wada K (August 1997).
"A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide". The Journal of Neuroscience. 17 (15): 5760–71.
doi:
10.1523/JNEUROSCI.17-15-05760.1997.
PMC
6573208.
PMID
9221774.
-
^ Sekiguchi M, Yamada K, Jin J, Hachitanda M, Murata Y, Namura S, et al. (September 2001). "The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment". NeuroReport. 12 (13): 2947–50.
doi:
10.1097/00001756-200109170-00038.
PMID
11588608.
S2CID
42785890.
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AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor | |
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KARTooltip Kainate receptor | |
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NMDARTooltip N-Methyl-D-aspartate receptor | |
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