From Wikipedia, the free encyclopedia
Chemical compound
6-Fluoronorepinephrine (6-FNE ) is a
selective
α1 - and
α2 -adrenergic receptor
full agonist related to
norepinephrine .
[1]
[2] It is the only selective full agonist for the
α-adrenergic receptors known to date and has been used to study their function in scientific research.
[2] Infusion of 6-FNE into the
locus coeruleus of rodents produces marked
hyperactivity and
behavioral disinhibition by suppressing activity in the area via stimulation of α1 -adrenergic receptors.
[2]
[3]
References
^ Kirk KL, Cantacuzene D, Nimitkitpaisan Y, McCulloh D, Padgett WL, Daly JW, Creveling CR (1979). "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry . 22 (12): 1493–7.
doi :
10.1021/jm00198a012 .
PMID
231654 .
^
a
b
c Stone EA, Lin Y, Sarfraz Y, Quartermain D (2009).
"Marked behavioral activation from inhibitory stimulation of locus coeruleus α1 -adrenoceptors by a full agonist" . Brain Research . 1291 : 21–31.
doi :
10.1016/j.brainres.2009.07.049 .
PMC
2735576 .
PMID
19632210 .
^ Stone EA, Grunewald GL, Lin Y, Ahsan R, Rosengarten H, Kramer HK, Quartermain D (2003). "Role of epinephrine stimulation of CNS α1 -adrenoceptors in motor activity in mice". Synapse . 49 (1): 67–76.
doi :
10.1002/syn.10212 .
PMID
12710017 .
S2CID
35324292 .
α1
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Abanoquil
Ajmalicine
Alfuzosin
Anisodamine
Anisodine
Atiprosin
Atypical antipsychotics (e.g.,
brexpiprazole ,
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olanzapine ,
quetiapine ,
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Benoxathian
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arotinolol ,
carvedilol ,
eugenodilol ,
labetalol )
Buflomedil
Bunazosin
Corynanthine
Dapiprazole
Domesticine
Doxazosin
Ergolines (e.g.,
acetergamine ,
ergotamine ,
dihydroergotamine ,
lisuride ,
nicergoline ,
terguride )
Etoperidone
Fenspiride
Hydroxyzine
Indoramin
Ketanserin
L-765,314
mCPP
Mepiprazole
Metazosin
Monatepil
Moxisylyte
Naftopidil
Nantenine
Neldazosin
Niaprazine
Niguldipine
Pardoprunox
Pelanserin
Perlapine
Phendioxan
Phenoxybenzamine
Phentolamine
Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone ,
nefazodone ,
trazodone ,
triazoledione )
Piperoxan
Prazosin
Quinazosin
Quinidine
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Spiperone
Talipexole
Tamsulosin
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amitriptyline ,
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Trimazosin
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WB-4101
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1-PP
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brexpiprazole ,
clozapine ,
lurasidone ,
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paliperidone ,
quetiapine ,
risperidone ,
zotepine )
Azapirones (e.g.,
buspirone ,
gepirone ,
ipsapirone ,
tandospirone )
BRL-44408
Buflomedil
Cirazoline
Efaroxan
Esmirtazapine
Fenmetozole
Fluparoxan
Idazoxan
Ketanserin
Lisuride
mCPP
Mianserin
Mirtazapine
NAN-190
Pardoprunox
Phentolamine
Phenoxybenzamine
Piperoxan
Piribedil
Rauwolscine
Rotigotine
Setiptiline
Spegatrine
Spiroxatrine
Sunepitron
Terguride
Tolazoline
Typical antipsychotics (e.g.,
chlorpromazine ,
fluphenazine ,
loxapine ,
thioridazine )
Yohimbine
β