From Wikipedia, the free encyclopedia
Chemical compound
TC-2216 is a drug developed by
Targacept which acts as a
partial agonist at neural
nicotinic acetylcholine receptors and was researched for the treatment of
anxiety and
depression.
[1] It was unsuccessful as a therapeutic but is still used in pharmacological research as an alpha4beta2-selective antagonist.
[2]
References
-
^ Romanelli MN, Gratteri P, Guandalini L, Martini E, Bonaccini C, Gualtieri F (June 2007). "Central nicotinic receptors: structure, function, ligands, and therapeutic potential". ChemMedChem. 2 (6): 746–67.
doi:
10.1002/cmdc.200600207.
PMID
17295372.
S2CID
34763474.
-
^ Lippiello PM, Beaver JS, Gatto GJ, James JW, Jordan KG, Traina VM, Xie J, Bencherif M (2008).
"TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity". CNS Neuroscience & Therapeutics. 14 (4): 266–77.
doi:
10.1111/j.1755-5949.2008.00054.x.
PMC
6494058.
PMID
19040552.
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SSRIsTooltip Selective serotonin reuptake inhibitors | |
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SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors | |
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NRIsTooltip Norepinephrine reuptake inhibitors | |
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NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors | |
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NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants | |
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SARIsTooltip Serotonin antagonist and reuptake inhibitors | |
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SMSTooltip Serotonin modulator and stimulators | |
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Others | |
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TCAsTooltip Tricyclic antidepressants | |
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TeCAsTooltip Tetracyclic antidepressants | |
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Others | |
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Non-selective | |
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MAOATooltip Monoamine oxidase A-selective | |
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MAOBTooltip Monoamine oxidase B-selective | |
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nAChRsTooltip Nicotinic acetylcholine receptors |
Agonists (and
PAMsTooltip positive allosteric modulators) |
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5-HIAA
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6-Chloronicotine
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A-84,543
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A-366,833
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A-582,941
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A-867,744
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ABT-202
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ABT-418
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ABT-560
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ABT-894
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Acetylcholine
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Altinicline
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Anabasine
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Anatabine
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Anatoxin-a
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AR-R17779
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Bephenium hydroxynaphthoate
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Butinoline
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Butyrylcholine
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Carbachol
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Choline
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Cotinine
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Cytisine
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Decamethonium
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Desformylflustrabromine
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Dianicline
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Dimethylphenylpiperazinium
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Epibatidine
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Epiboxidine
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Ethanol (alcohol)
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Ethoxysebacylcholine
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EVP-4473
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EVP-6124
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Galantamine
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GTS-21
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Ispronicline
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Ivermectin
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JNJ-39393406
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Levamisole
-
Lobeline
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MEM-63,908 (RG-3487)
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Morantel
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Nicotine (
tobacco)
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NS-1738
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PHA-543,613
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PHA-709,829
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PNU-120,596
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PNU-282,987
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Pozanicline
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Pyrantel
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Rivanicline
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RJR-2429
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Sazetidine A
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SB-206553
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Sebacylcholine
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SIB-1508Y
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SIB-1553A
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SSR-180,711
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Suberyldicholine
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Suxamethonium (succinylcholine)
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Suxethonium (succinyldicholine)
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TC-1698
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TC-1734
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TC-1827
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TC-2216
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TC-5214
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TC-5619
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TC-6683
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Tebanicline
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Tribendimidine
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Tropisetron
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UB-165
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Varenicline
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WAY-317,538
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XY-4083
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Antagonists (and
NAMsTooltip negative allosteric modulators) | |
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Precursors (and
prodrugs) | |
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