From Wikipedia, the free encyclopedia
Chemical compound
Camylofin is an
antimuscarinic drug.
[1]
Camylofin is a
smooth muscle relaxant with both
anticholinergic action as well as direct
smooth muscle action. Anticholinergic action is produced by inhibiting the binding of
acetylcholine to
muscarinic receptors , but the action is less pronounced.[
citation needed ] Direct smooth muscle relaxation is achieved by inhibiting
phosphodiesterase type IV, which leads to increased
cyclic AMP and eventually reduced
cytosolic calcium. Thus camylofin has a comprehensive action to relieve smooth muscle
spasm . It is used to treat stomach ache in infants and children. Usually it is given in combination with
paracetamol to treat stomach ache, as well as
pyrexia .
[2]
Synthesis
Synthesis:
[3]
[4] Patents:
[5]
[6]
[7] Metamizole salt patents:
[8]
[9]
[10]
The
Hell–Volhard–Zelinsky halogenation on phenylacetic acid [103-82-2] (1 ) gives 2-Bromo-2-phenylacetyl bromide,
CID:15621041 (2 ). Treatment with
isoamyl alcohol [123-51-3] gives 3-methylbutyl bromo(phenyl)acetate [92018-48-9] (3 ). Alkylation with N,N-Diethylethylenediamine [100-36-7] (4 ) completed the synthesis of Camylofin (5 ).
References
^
"Camylofin" . PubChem . Retrieved 2019-06-02 .
^ Sarbhjit K, Bajwa SK, Parmjit K, Surinder B (September 2013).
"To compare the effect of camylofin dihydrochloride (anafortin) with combination of valethamate bromide (epidosin) and hyoscine butyl-N-bormide (buscopan) on cervical dilation" . Journal of Clinical and Diagnostic Research . 7 (9): 1897–9.
doi :
10.7860/JCDR/2013/6231.3345 .
PMC
3809631 .
PMID
24179892 .
^ Bruzzese, Tiberio; Crescenzi, Elda (1966). "N-Aminoalkyl-α-aminoacids and Their Corresponding Ethyl Esters". Journal of Pharmaceutical Sciences. 55 (7): 737–740. doi:10.1002/jps.2600550717.
^ Szarvasi, E. et al, Bull. Soc. Chim. Fr., 1957, 1019.
^ Brock Norbert, Kuhas Engelbert, & Schmeisser Martin,
U.S. patent 2,665,300 (1954 to Asta Medica AG).
^ Martin Dr-Chem Schmeisser, Engelbert Dr Phil Kuehas, Norbert Dr Med Brock, DE842206 (1952 to Asta Werke Ag Chem Fab).
^ , GB688331 (1953 to Asta Medica AG).
^ , GB782068 (1957 to Asta Medica AG).
^ Kuhas Engelbert, Brock Norbert, & Arnold Herbert, CA566251 (1958 to Asta Medica AG).
^ Arnold Herbert, Kuhas Engelbert, & Brock Norbert,
U.S. patent 2,857,395 (1958).
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