ORG-26576 is an
ampakine originally developed by
Cortex Pharmaceuticals and then licensed to
Organon International for development. In animal studies it has been shown to effectively potentiate
AMPA receptor function, leading to increased
BDNF release and enhanced neuronal differentiation and survival, as well as producing
nootropic effects in standardised assays.[1][2][3][4][5][6] Development as an antidepressant has been halted due to a failed Phase II trial for
major depressive disorder.[7]
^Jordan GR, McCulloch J, Shahid M, Hill DR, Henry B, Horsburgh K (August 2005). "Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography". Neuropharmacology. 49 (2): 254–64.
doi:
10.1016/j.neuropharm.2005.03.011.
PMID15993447.
S2CID24805124.
^Su XW, Li XY, Banasr M, Koo JW, Shahid M, Henry B, Duman RS (October 2009). "Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus". Psychopharmacology. 206 (2): 215–22.
doi:
10.1007/s00213-009-1598-0.
PMID19603152.
S2CID19408716.
^Hamlyn E, Brand L, Shahid M, Harvey BH (October 2009). "The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats". Behavioural Pharmacology. 20 (7): 662–7.
doi:
10.1097/FBP.0b013e328331ba1b.
PMID19741506.
S2CID27814943.
^Bursi R, Erdemli G, Campbell R, Hutmacher MM, Kerbusch T, Spanswick D, et al. (December 2011). "Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576". Psychopharmacology. 218 (4): 713–24.
doi:
10.1007/s00213-011-2365-6.
PMID21647578.
S2CID20634325.
^Jardemark K, Marcus MM, Malmerfelt A, Shahid M, Svensson TH (May 2012). "Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission". Psychopharmacology. 221 (1): 115–31.
doi:
10.1007/s00213-011-2554-3.
PMID22068461.
S2CID253749292.
^Fumagalli F, Calabrese F, Luoni A, Shahid M, Racagni G, Riva MA (February 2012). "The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus". Pharmacological Research. 65 (2): 176–81.
doi:
10.1016/j.phrs.2011.10.004.
PMID22079295.