From Wikipedia, the free encyclopedia
Chemical compound
Orciprenaline , also known as metaproterenol , is a
bronchodilator used in the treatment of
asthma .
[1]
[2] Orciprenaline is a moderately selective
β2 adrenergic receptor agonist that stimulates receptors of the
smooth muscle in the lungs, uterus, and vasculature supplying
skeletal muscle , with minimal or no effect on α adrenergic receptors. The pharmacologic effects of β adrenergic
agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through β adrenergic receptors of intracellular
adenylyl cyclase , the enzyme which catalyzes the conversion of
ATP to
cAMP . Increased cAMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of
immediate hypersensitivity from many cells, especially from
mast cells .
Possible side effects
tremor
nervousness
dizziness
weakness
headache
nausea
tachycardia
Rare side effects that could be life-threatening
increased difficulty breathing
rapid or increased heart rate
irregular heartbeat
chest pain or discomfort
Brand names
Alupent
Metaprel
Orcibest
References
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011).
"DrugBank 3.0: a comprehensive resource for omics research on drugs" . Nucleic Acids Res . 39 (Database issue): D1035-41.
doi :
10.1093/nar/gkq1126 .
PMC
3013709 .
PMID
21059682 .
^
Wishart DS , Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008).
"DrugBank: a knowledgebase for drugs, drug actions and drug targets" . Nucleic Acids Res . 36 (Database issue): D901-6.
doi :
10.1093/nar/gkm958 .
PMC
2238889 .
PMID
18048412 .
α1
Agonists Antagonists
Abanoquil
Ajmalicine
Alfuzosin
Anisodamine
Anisodine
Atiprosin
Atypical antipsychotics (e.g.,
brexpiprazole ,
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Benoxathian
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L-765,314
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WB-4101
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1-PP
Adimolol
Amesergide
Aptazapine
Atipamezole
Atypical antipsychotics (e.g.,
asenapine ,
brexpiprazole ,
clozapine ,
lurasidone ,
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Azapirones (e.g.,
buspirone ,
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tandospirone )
BRL-44408
Buflomedil
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NAN-190
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Setiptiline
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Sunepitron
Terguride
Tolazoline
Typical antipsychotics (e.g.,
chlorpromazine ,
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loxapine ,
thioridazine )
Yohimbine
β