From Wikipedia, the free encyclopedia
Stimulant and entactogen drug
Mexedrone (also known as 4-MMC -MeO ) is a
stimulant and an
entactogen
drug of the
cathinone
class that has been sold online as a
designer drug .
[1]
[2]
[3]
[4] It is the alpha-methoxy
derivative of
Mephedrone .
Pharmacology
Mexedrone acts as a weak
serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with
IC50 values of 5289 nM, 8869 nM and 6844 nM, respectively, as well as a weak
serotonin releasing agent (SRA) with an
EC50 value of 2525 nM.
[5]
Legal status
Mexedrone is illegal in Sweden as of January 26, 2016
[6] as well as Japan as of August 24, 2016.
[7]
See also
References
^
"Mexedrone" . New Synthetic Drug Database .
^ Qian Z, Jia W, Li T, Liu C, Hua Z (February 2017). "Identification and analytical characterization of four synthetic cathinone derivatives iso-4-BMC, β-TH-naphyrone, mexedrone, and 4-MDMC". Drug Testing and Analysis . 9 (2): 274–281.
doi :
10.1002/dta.1983 .
PMID
27352812 .
^ Kuś P, Rojkiewicz M, Kusz J, Książek M, Sochanik A (14 May 2019).
"Spectroscopic characterization and crystal structures of four hydrochloride cathinones: N-ethyl-2-amino-1-phenylhexan-1-one (hexen, NEH), N-methyl-2-amino-1-(4-methylphenyl)-3-methoxypropan-1-one (mexedrone), N-ethyl-2-amino-1-(3,4-methylenedioxyphenyl)pentan-1-one (ephylone) and N-butyl-2-amino-1-(4-chlorophenyl)propan-1-one (4-chlorobutylcathinone)" . Forensic Toxicology . 37 (2): 456–464.
doi :
10.1007/s11419-019-00477-y .
hdl :
20.500.12128/9638 .
^ Roberts L, Ford L, Patel N, Vale JA, Bradberry SM (March 2017). "11 analytically confirmed cases of mexedrone use among polydrug users". Clinical Toxicology . 55 (3): 181–186.
doi :
10.1080/15563650.2016.1271424 .
PMID
28075189 .
S2CID
33220365 .
^ McLaughlin G, Morris N, Kavanagh PV, Power JD, Dowling G, Twamley B, et al. (March 2017).
"Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone" . Drug Testing and Analysis . 9 (3): 358–368.
doi :
10.1002/dta.2053 .
PMC
5336524 .
PMID
27524685 .
^
"31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. November 2015.
^
"指定薬物一覧" (PDF) (in Japanese). Ministry of Health, Labour and Welfare.