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Quinupramine
Clinical data
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Elimination half-life33 hours
Identifiers
  • (±)-11-quinuclidin-3-yl-5,6-dihydrobenzo[b][1]benzazepine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ECHA InfoCard 100.046.149 Edit this at Wikidata
Chemical and physical data
FormulaC21H24N2
Molar mass304.437 g·mol−1

Quinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression. [1] [2]

Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist ( anticholinergic) and H1 receptor antagonist ( antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor. [3] It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor. [3]

Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline. [4] It can be inferred that its in vivo metabolites may have stronger effects on the reuptake of norepinephrine and/or serotonin than quinupramine itself.[ citation needed]

References

  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 908. ISBN  3-88763-075-0.
  2. ^ Vela JM, Buschmann H, Holenz J, Párraga A, Torrens A (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 248. ISBN  978-3-527-31058-6.
  3. ^ a b Sakamoto H, Yokoyama N, Kohno S, Ohata K (December 1984). "Receptor binding profile of quinupramine, a new tricyclic antidepressant". Japanese Journal of Pharmacology. 36 (4): 455–460. doi: 10.1254/jjp.36.455. PMID  6098759.
  4. ^ Kent A, Billiard M (2003). Sleep: physiology, investigations, and medicine. New York: Kluwer Academic/Plenum. p. 233. ISBN  0-306-47406-9.
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