From Wikipedia, the free encyclopedia
Enzyme
In
biochemistry , a dual-specificity kinase (
EC
2.7.12.1 ) is a
kinase that can act as both
tyrosine kinase and
serine/threonine kinase .
MEKs , involved in
MAP pathways , are principal examples of dual-specificity kinases. Other common examples include:
The
systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) .
References
Dhanasekaran N, Premkumar Reddy E (1998).
"Signaling by dual specificity kinases" . Oncogene . 17 (11 Reviews): 1447–1455.
doi :
10.1038/sj.onc.1202251 .
PMID
9779990 .
Ali N, Halfter U, Chua NH (1994). "Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine". J. Biol. Chem . 269 (50): 31626–9.
PMID
7527390 .
Lauze E, Stoelcker B, Luca FC, Weiss E, Schutz AR, Winey M (1995).
"Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase" . EMBO J . 14 (8): 1655–63.
PMC
398258 .
PMID
7737118 .
Menegay HJ, Myers MP, Moeslein FM, Landreth GE. "Biochemical characterization and localization of the dual specificity kinase CLK1". J. Cell Sci . 113 : 3241–53.
PMID
10954422 .
Cleghon V; Sibbet, G; Kinstrie, R; Cleghon, T; Rylatt, M; Morrison, DK; Cleghon, V (2003).
"dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila" . Biochem. J . 374 (Pt 2): 381–91.
doi :
10.1042/BJ20030500 .
PMC
1223608 .
PMID
12786602 .
Activity Regulation Classification Kinetics Types