From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an
enzyme that in humans is encoded by the MAPK13
gene .
[5]
Function
The protein encoded by this gene is a member of the
MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation ,
differentiation ,
transcription regulation and
development . This kinase is closely related to
p38 MAP kinase , both of which can be activated by proinflammatory
cytokines and cellular stress. MAP kinase kinases 3, and 6 can
phosphorylate and activate this kinase. Transcription factor
ATF2 , and microtubule dynamics regulator
stathmin have been shown to be the
substrates of this kinase.
[5]
References
Further reading
Efimova T, Broome AM, Eckert RL (2004).
"Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex" . Mol. Cell. Biol . 24 (18): 8167–83.
doi :
10.1128/MCB.24.18.8167-8183.2004 .
PMC
515052 .
PMID
15340077 .
Joneson T, Bar-Sagi D (1997). "Ras effectors and their role in mitogenesis and oncogenesis". J. Mol. Med . 75 (8): 587–93.
doi :
10.1007/s001090050143 .
PMID
9297626 .
S2CID
23541383 .
Efimova T (2010).
"p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis" . Cell Cycle . 9 (3): 498–05.
doi :
10.4161/cc.9.3.10541 .
PMID
20090411 .
Gutierrez-Sanmartin D, Varela-Ledo E, Aguilera A, et al. (2008).
"Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I." J. Gen. Virol . 89 (Pt 7): 1661–71.
doi :
10.1099/vir.0.82971-0 .
PMID
18559936 .
Zhang J, Harrison JS, Studzinski GP (2011).
"Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃" . Exp. Cell Res . 317 (1): 117–30.
doi :
10.1016/j.yexcr.2010.08.010 .
PMC
2998239 .
PMID
20804750 .
Segat L, Brandão LA, Guimarães RL, et al. (2010).
"Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment" . Vaccine . 28 (10): 2201–6.
doi :
10.1016/j.vaccine.2009.12.056 .
PMID
20056178 .
Zhou X, Ferraris JD, Dmitrieva NI, et al. (2008).
"MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta" . Proc. Natl. Acad. Sci. U.S.A . 105 (14): 5620–5.
Bibcode :
2008PNAS..105.5620Z .
doi :
10.1073/pnas.0801453105 .
PMC
2291081 .
PMID
18367666 .
Coulthard LR, Taylor JC, Eyre S, et al. (2011). "Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients". Ann. Rheum. Dis . 70 (1): 98–103.
doi :
10.1136/ard.2010.133249 .
PMID
20805296 .
S2CID
37511360 .
Efimova T, Broome AM, Eckert RL (2003).
"A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation" . J. Biol. Chem . 278 (36): 34277–85.
doi :
10.1074/jbc.M302759200 .
PMID
12810719 .
Kim SJ, Zhang Z, Hitomi E, et al. (2006).
"Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL" . Hum. Mol. Genet . 15 (11): 1826–34.
doi :
10.1093/hmg/ddl105 .
PMID
16644870 .
Talmud PJ, Drenos F, Shah S, et al. (2009).
"Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip" . Am. J. Hum. Genet . 85 (5): 628–42.
doi :
10.1016/j.ajhg.2009.10.014 .
PMC
2775832 .
PMID
19913121 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003).
"The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11.
Bibcode :
2003Natur.425..805M .
doi :
10.1038/nature02055 .
PMID
14574404 .
Colland F, Jacq X, Trouplin V, et al. (2004).
"Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32.
doi :
10.1101/gr.2334104 .
PMC
442148 .
PMID
15231748 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Ozawa S, Ito S, Kato Y, et al. (2010). "Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14". Biochem. Biophys. Res. Commun . 396 (4): 1060–4.
doi :
10.1016/j.bbrc.2010.05.072 .
PMID
20478268 .
Kitatani K, Sheldon K, Anelli V, et al. (2009).
"Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid" . J. Biol. Chem . 284 (19): 12979–88.
doi :
10.1074/jbc.M809500200 .
PMC
2676030 .
PMID
19279008 .
Tan FL, Ooi A, Huang D, et al. (2010).
"p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion" . Int. J. Cancer . 126 (10): 2353–61.
doi :
10.1002/ijc.24944 .
PMID
19816939 .
S2CID
34276751 .
Sofroniew MV, Howe CL,
Mobley WC (2001). "Nerve growth factor signaling, neuroprotection, and neural repair". Annu. Rev. Neurosci . 24 : 1217–81.
doi :
10.1146/annurev.neuro.24.1.1217 .
PMID
11520933 .
Bailey SD, Xie C, Do R, et al. (2010).
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study" . Diabetes Care . 33 (10): 2250–3.
doi :
10.2337/dc10-0452 .
PMC
2945168 .
PMID
20628086 .
Sumara G, Formentini I, Collins S, et al. (2009).
"Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis" . Cell . 136 (2): 235–48.
doi :
10.1016/j.cell.2008.11.018 .
PMC
2638021 .
PMID
19135240 .
Activity Regulation Classification Kinetics Types
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .